Front Cover; Advances in Immunology, Volume 48; Copyright Page; Contents; Chapter 1. Internal Movements in Immunoglobulin Molecules; I. Introduction; II. Methods for the Study of Ig Flexibility; III. Segmental Flexibility of Ig Molecules; IV. Internal Motions in Fab and Fc Subunits; V. Role of the Hinge Region Structure for Segmental Flexibility; VI. Functional Implications of Segmental Flexibility; VII. Evolution of Ig Flexibility; VIII. Mobility of Carbohydrate Components; IX. Conclusions; References; Chapter 2. Somatic Diversification of the Chicken Immunoglobulin light-Chain Gene.
I. IntroductionII. Bursa of Fabricius Is Essential for Normal B Cell Development; III. Structure of the Unique Chicken IgL Gene; IV. Rearrangement of the IgL, Gene; V. Early Role of the Bursa: Selection if Ig+ Precursors; VI. Bursal Stem Cell; VII. Developing Bursal Lymphocytes Acquire Diversity within the Rearranged IgL Gene Segment; VIII. Sequences That Lead to Diversification of the Rearranged VL Gene Segment Have Identical Counterparts in the fV Gene Segments Located 5' of VL.; IX. Diversification Results in a Cell in Which the VL Gene Segment Has Undergone Conversion.
II. Corneal Allografts: Immunogenically Privileged Grafts on Immunologically Privileged Graft BedsIII. Immunological Privilege of the Anterior Chamber; IV. Effect of Immune Regulation on Intraocular Tumor Rejection; V. Immune Regulation and Autoimmune Uveitis; VI. Uveitis: A Breakdown in Self-Tolerance and Immune Privilege; VII. Is Cataract Formation an Immune-Mediated Disease?; VIII. Conclusions; References; Chapter 7. Molecular Events Mediating T Cell Activation; I. Introduction; II. T Cell Surface Activation Molecules; III. PI Turnover and Formation of Second Messengers in T Cells.
II. HLA Class II Structures: Genes and MoleculesIII. HLA Class II Polymorphism and Typing; IV. HLA Class II Hybrid (Intra- or Interisotypic) Molecules; V. Diseases; VI. Concluding Remarks and Perspectives; References; Chapter 5. Neuroimmunology; I. Introduction; II. T Cell Components of Autoimmune Reactions to the Nervous System; III. Production and Functional Effects of Cytokines and Other Mediators of Neuroimmunological Reactions; IV. Lymphocyte Receptors for Neuromediators; V. Conclusions; References; Chapter 6. Immune Privilege and Immune Regulation in the Eye; I. Introduction.
X. Somatic Diversification of the Ig VL Gene Repertoire by Gene Conversion Is a General Feature of Avian Ig GenesXI. Additional Mechanisms of Ig Diversification; XII. Summary; References; Chapter 3. T Lymphocyte-Derived Colony-Stimulating Factors; I. Introduction; II. Colony-Stimulating Factors; III. T Lymphocyte Production of CSFs in Vitro; IV. Inducibility and Regulation of CSF Synthesis; V.T Lymphocyte Heterogeneity; VI. CSF Production of T Lymphocytes in Vivo; References; Chapter 4. The Molecular Basis of Human Leukocyte Antigen Class II Disease Associations; I. Introduction.