عنوان

Advances in immunology.

008057839X

0120224631

9780080578392

9780120224630

b725858

Advances in immunology.

[Book]

edited by Frank J. Dixon.

Volume 63 /

New York :

Academic Press,

©1996.

1 online resource (x, 468 pages) :

illustrations.

Advances in Immunology ;

v. 63

Includes bibliographical references and index.

Front Cover; Advances in Immunology, Volume 63; Copyright Page; Contents; Contributors; Chapter 1. Surrogate Light Chain in B Cell Development; I. Introduction; II. Surrogate Light Chain Genes and Their Regulation; III. Expression of Surrogate Light Chain; IV. Functional Roles of Surrogate Light Chain in B Cell Development; V. Ligand and Signal Transduction of Surrogate Light Chain Complex; VI. Other Surrogate Light Chain-like Molecules; VII. Concluding Remarks; References; Chapter 2. CD40 and Its Ligand; I. Introduction; II. CD40 and Ligand Expression and Molecular Structure.

III. Cytokine Receptors: Membrane and Soluble FormsIV. Production of Soluble Cytokine Receptors; V. The Immunoregulatory Function of Soluble Cytokine Receptors; VI. The Properties of Soluble Cytokine Receptors and Relationship to Disease; VII. Soluble Cytokine Receptors and Therapy; VIII. Summary and Conclusions; References; Chapter 7. Cytokine Expression and Cell Activation in Inflammatory Arthritis; I. Introduction; II. The Inflammatory Synovial Environment; III. Assessment of Cytokine Expression and Activity in Synovitis; IV. Pro-inflammatory Cytokines and Growth Factors.

III. Intracellular Signal Transduction through CD40IV. CD40-gp39 Functional Interactions; V. The Role of CD40 Signaling in B Lymphocyte Proliferation; VI. The Role of CD40 in Immunoglobulin Production; VII. The Role of CD40 in Germinal Center and Memory Cell Formation; VIII. Summary; References; Chapter 3. Human Immunodeficiency Virus Infection of Human Cells Transplanted to Severe Combined Immunodeficient Mice; I. Introduction; II. Description of Human-to-Mouse Xenograft Models; III. Human Immunodeficiency Virus; IV. HIV-1 Infection in the hu-PBL-SCID Model.

IX. Specific Signaling Molecules for IL-4, IL-9, IL-13, and Insulin ReceptorsX. Cooperation of the Three IL-2-Induced Signaling Pathways; XI. Concluding Remarks; References; Chapter 5. B Lymphocyte Development and Transcription Regulation in Vivo; I. Introduction; II. Transcription Regulation in Vivo; III. B Lymphocyte Development in Vivo in the Normal Mouse; IV. Transcription Factors in B Lymphocyte Genesis; V. Concluding Remarks; References; Chapter 6. Soluble Cytokine Receptors: Their Roles in Immunoregulation, Disease, and Therapy; I. Introduction; II. Regulation of Cytokine Activity.

V. HIV-1 Infection in the SCID-hu thy/liv ModelVI. Conclusions; References; Chapter 4. Lessons from Immunological, Biochemical, and Molecular Pathways of the Activation Mediated by IL-2 and IL-4; I. Introduction; II. Cell Surface Receptors for IL-2 and IL-4; III. From Nonreceptor Protein Tyrosine Kinases to Adaptor Molecules; IV. From Ras to the MAPK Pathway; V. From the GTP-Binding Protein Rho to Control of the Cytoskeleton; VI. Nuclear Transcription Factor NF-kB; VII. Target Genes in IL-2 Signals; VIII. The Counterpart of Protein Kinases: The Phosphoprotein Phosphatases.

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Praise for the Series: "The series which all immunologists need."--The Pharmaceutical Journal "Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."--Science "Deserves a permanent place in biomedical libraries as an aid in research and in teaching."--Journal of Immunological Methods Key Features: * The role of CD40 and its ligand, gp39, as central players in the regulation of B cell growth and differentiation * Prolactin, growth hormone and insulin-like growth factor-I as full-fledged immunological growth and differentiation factors * Transcription factors of functionally mutant mice are highly relevant to understanding hemopoiesis and B cell genesis in vivo HIV infection of xenotransplanted mice compared with natural HIV and SIV infections * The expression and role of cytokines in Rheumatoid Arthritis and in seronegative arthritis * The functions of the surrogate light chain in B cell development * Mechanisms that regulate cytokine activity and the generation and function of sCR as cytokine anatogonists and/or cytokine "carriers" in vivo * Potential transducing molecules involved in signaling processes and which mark the difference between signaling through IL-2R and IL-4R.

Advances in immunology. Volume 63.

9780120224630

Immunology.

Immunologie.

Immunology.

MEDICAL-- Immunology.

MED-- 044000

Dixon, Frank J., (Frank James),1920-2008.

20201213184045.0

pn

[Book]

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