Tissue engineering of cartilage : do we need it, can we do it, is it good and can we prove it? / L. Stefan Lohmander -- Embryonic development and the principles of tissue engineering / Arnold I. Caplan -- The fundamentals of tissue engineering : scaffolds and bioreactors / Gordana Vunjak-Novakovic -- Tissue-engineered versus native cartilage : linkage between cellular mechano-transduction and biomechanical properties / Jennifer H. Lee, John Kisiday and Alan J. Grodzinsky -- From the preclinical model to the patient / Ernst B. Hunziker -- Mesenchymal stem cell therapy in joint disease / Frank P. Barry -- Differentiated chondrocytes for cartilage tissue engineering / J. Huckle, G. Dootson, N. Medcalf, S. McTaggart, E. Wright, A. Carter, R. Schreiber, B. Kirby, N. Dunkelman, S. Stevenson, S. Riley, T. Davisson and A. Ratcliffe -- Mesenchymal stem cells and bioceramics : strategies to regenerate the skeleton / Hajime Ohgushi, Jun Miyake and Tetsuya Tateishi -- Bone marrow stromal cells and their use in regenerating bone / Ranieri Cancedda, Maddalena Mastrogiacomo, Giordano Bianchi, Anna Derubeis, Anita Muraglia and Rodolfo Quarto -- Studying the effect of different macrostructures on in vitro cell behaviour and in vivo bone formation using a tissue engineering approach / R.J. Dekker, C.A. van Blitterswijk, I. Hofland, P.J. Engelberts, J. Li and J.D. de Bruijn -- Cartilage repair with chondrocytes : clinical and cellular aspects / Anders Lindahl, Mats Brittberg and Lars Peterson -- Qualitative and quantitative in vivo assessment of articular cartilage using magnetic resonance imaging / Elizabeth O'Byrne, Theodore Pellas and Didier Laurent -- Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects : preliminary clinical findings / Alessandra Pavesio, Giovanni Abatangelo, Anna Borrione, Domenico Brocchetta, Anthony P. Hollander, Elizaveta Kon, Francesca Torasso, Stefano Zanasi and Maurilio Marcacci -- Quantitative analysis of repair tissue biopsies following chondrocyte implantation / Anthony P. Hollander, Sally C. Dickinson, Trevor J. Sims, Carlo Soranzo and Alessandra Pavesio.
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In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have been significant stumbling blocks holding back the widespread use of these techniques in the clinic. These challenges, and potential ways of overcoming them, are given thorough coverage in the discussions that follow each chapter.
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