عنوان

CNS cancer :

1603275525

1603275533

9781603275521

9781603275538

b702088

CNS cancer :

[Book]

models, markers, prognostic factors, targets, and therapeutic approaches /

Erwin G. Van Meir, editor.

New York :

Humana Press,

©2009.

1 online resource (1 volume) :

color illustrations

Cancer Drug Discovery and Development

Includes bibliographical references and index.

Animal Models for Central Nervous Tumors -- Modeling Gliomas Using PDGF-Expressing Retroviruses -- Modeling Brain Tumors Using Avian Retroviral Gene Transfer -- Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomas -- Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme -- Pten-Deficient Mouse Models for High-Grade Astrocytomas -- The Nf1-/+; Trp53-/+cis Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptibility to Brain Cancer -- Modeling Astrocytomas in a Family of Inducible Genetically Engineered Mice: Implications for Preclinical Cancer Drug Development -- Human Brain Tumor Cell and Tumor Tissue Transplantation Models -- Transformed Human Brain Cells in Culture as a Model for Brain Tumors -- Rat Glioma Models for Preclinical Evaluation of Novel Therapeutic and Diagnostic Modalities -- Neuro-oncogenesis Induced by Nitroso Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition -- The Murine GL261 Glioma Experimental Model to Assess Novel Brain Tumor Treatments -- Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems -- Prognostic Factors and Biomarkers -- p53 Pathway Alterations in Brain Tumors -- The PTEN/PI3 Kinase Pathway in Human Glioma -- Value of 1p/19q and Other LOH Markers for Brain Tumor Diagnosis, Prognosis, and Therapy -- Discovery of Genetic Markers for Brain Tumors by Comparative Genomic Hybridization -- Genomic Identification of Significant Targets in Brain Cancer -- Oncomodulatory Role of the Human Cytomegalovirus in Glioblastoma -- Aberrant EGFR Signaling in Glioma -- Mechanisms of Brain Tumor Angiogenesis -- Vaso-occlusive Mechanisms that Intiate Hypoxia and Necrosis in Glioblastoma: The Role of Thrombosis and Tissue Factor -- Transcription Profiling of Brain Tumors: Tumor Biology and Treatment Stratification -- Proteomic Profiling of Human Brain Tumors -- Proteomic Discovery of Biomarkers in the Cerebrospinal Fluid of Brain Tumor Patients -- Epigenetic Profiling of Gliomas -- MicroRNAs in the Central Nervous System and Potential Roles of RNA Interference in Brain Tumors -- Of Escherichia coli and Man: Understanding Glioma Resistance to Temozolomide Therapy -- Brain Tumor Stem Cell Markers -- Therapeutic Targets and Targeting Approaches -- Clinical Agents for the Targeting of Brain Tumor Vasculature -- Bone Marrow-Derived Cells in GBM Neovascularization -- Vascular Targeting of Brain Tumors -- Bridging the Gap with Phage Display -- Impact of the Blood-Brain Barrier on Brain Tumor Imaging and Therapy -- Targeting CXCR4 in Brain Tumors -- Molecular Targeting of IL-13R?2 and EphA2 Receptor in GBM -- Molecular Targets for Antibody-Mediated Immunotherapy of Malignant Glioma -- Stat3 Oncogenic Signaling in Glioblastoma Multiforme -- Inhibition of Ras Signaling for Brain Tumor Therapy -- HGF/c-Met Signaling and Targeted Therapeutics in Brain Tumors -- Combinatorial Therapeutic Strategies for Blocking Kinase Pathways in Brain Tumors -- Targeting of TRAIL Apoptotic Pathways for Glioblastoma Therapies -- The NF-?B Signaling Pathway in GBMs: Implications for Apoptotic and Inflammatory Responses and Exploitation for Therapy -- Targeting Endoplasmic Reticulum Stress for Malignant Glioma Therapy -- Brain Cancer Stem Cells as Targets of Novel Therapies -- The Use of Retinoids as Differentiation Agents Against Medulloblastoma -- Herpes Simplex Virus 1 (HSV-1) for Glioblastoma Multiforme Therapy -- The Development of Targeted Cancer Gene-Therapy Adenoviruses for High-Grade Glioma Treatment -- Harnessing T-Cell Immunity to Target Brain Tumors -- Glioma Invasion: Mechanisms and Therapeutic Challenges.

0

Covers three areas of research in brain tumors such as animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; prognostic factors and biomarkers; and, therapeutic targets and targeting approaches to brain tumors.

Springer

978-1-60327-552-1

CNS cancer.

Central nervous system-- Cancer.

Central Nervous System Neoplasms.

Biomédecine.

Central nervous system-- Cancer.

Central nervous system-- Cancer.

Sciences de la vie.

Van Meir, Erwin G.

20201207174237.0

pn

[Book]

Y