عنوان

Role of tyrosine kinases in gastrointestinal malignancies /

9789811314865

9789811314872

9789811346408

9811314861

981131487X

9811346402

9789811314858

9811314853

Role of tyrosine kinases in gastrointestinal malignancies /

[Book]

Ganji Purnachandra Nagaraju, editor.

Singapore :

Springer,

2018.

1 online resource

Includes bibliographical references.

Intro; Dedication; Preface; Contents; Contributors; About the Editor; 1: HGFR and FGR2: Their Roles in Progression and Metastasis of Esophageal Cancer; 1.1 Introduction/Background; 1.2 Clinical Characteristics of Esophageal Cancer; 1.3 Structures of Hepatocyte Growth Factor Receptor (HGFR) and Fibroblast Growth Factor Receptor 2 (FGR2); 1.4 Expression and Roles of HGFR and FGFR2 in EC; 1.5 Signaling Pathways Related to HGFR and FGR2 in EC; 1.5.1 Structure and Functions of HGF and c-Met Receptors; 1.5.2 HGF-c-Met Signaling Mechanisms.

1.5.3 Role of MET Signaling in Physiologic and Pathologic Growth1.5.4 Structure, Functions, and Signaling of FGR2; 1.5.5 Role of FGFR2 in Esophageal Cancer; 1.6 Molecular-Targeted Therapy of the HGFR and FGFR2 in EC; 1.6.1 c-Met-Targeted Therapies, Adverse Reactions, and Relevant Clinical Trials; 1.6.2 FGFR-Targeted Therapies, Their Adverse Reactions, and Relevant Clinical Trials; 1.7 Economic/Financial Issues for Patients, Professionals, and Hospitals; 1.8 Conclusions and Future Perspectives; References; 2: Role of Src and VEGFR Tyrosine Kinases in Esophageal Cancer.

2.1 Introduction2.1.1 Src and Esophageal Cancer; 2.1.2 VEGFR (Vascular Endothelial Growth Factor) and Esophageal Cancer; References; 3: The Clinical and Biological Significance of Tyrosine Kinases in Gastric Cancer; 3.1 Introduction/Background; 3.2 Characterization of Gastric Cancer with Genomic and Molecular Analyses to Stratify the Heterogeneous Disease; 3.2.1 Genomics of Gastric Cancer; 3.2.2 Gene Mutations in Gastric Cancer; 3.2.3 Chromosomal Instability; 3.2.4 Transcriptional Changes in Gastric Cancer; 3.2.5 Epigenetic Modifications in Gastric Cancer.

3.2.6 Molecular and Genomic Stratification of Gastric Cancer3.3 Role of Tyrosine Kinases, Receptors, and Inhibitors in Gastric Cancer; 3.3.1 Receptor Tyrosine Kinases in Gastric Cancer; 3.3.2 Role of EGF Receptor/HER Tyrosine Kinase Family in Gastric Cancer; 3.3.3 Vascular Endothelial Growth Factor Receptor; 3.3.4 Fibroblast Growth Factor Receptor; 3.3.5 Platelet-Derived Growth Factor Receptor; 3.3.6 Combined VEGFR and PDGFR Tyrosine Kinase Inhibitors; 3.3.7 Hepatocyte Growth Factor Receptor Tyrosine Kinase; 3.4 Targeted Therapies and Ongoing Clinical Trials.

3.4.1 Targeted Therapies for HER-2 Overexpressed Gastric Cancers3.4.2 Ongoing Trials for HER-2 Targeted Therapies; 3.4.3 Targeted Therapies for the VEGF-Positive Gastric Cancers; 3.4.4 Trials for VEGF Targeted Therapies; 3.4.5 Anti-EGFR-Targeted Therapies and Trials; 3.4.6 Targeted Therapies for Gastric Cancers with FGFR2 Amplification; 3.4.7 Clinical Trials for FGFR2-Targeted Therapies; 3.4.8 Targeted Therapies for the PI3K Pathway and Clinical Trials; 3.4.9 Targeted Therapies and Clinical Trials for MET-Amplified Gastric Tumors; 3.4.10 Immunotherapy for Gastric Cancer.

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The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.

Springer Nature

com.springer.onix.9789811314865

Role of tyrosine kinases in gastrointestinal malignancies.

9789811314858

Digestive organs-- Cancer-- Diagnosis.

Digestive organs-- Cancer-- Treatment.

Protein-tyrosine kinase.

Cellular biology (cytology)

Digestive organs-- Cancer-- Diagnosis.

Medical genetics.

MEDICAL-- Physiology.

Oncology.

Physiology.

Proteins.

Protein-tyrosine kinase.

SCIENCE-- Life Sciences-- Human Anatomy & Physiology.

MED-- 075000

MJCL

MJCL

SCI-- 036000

Nagaraju, Ganji Purnachan

20200823224923.0

pn

[Book]

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