Overview. An overview of muscle atrophy -- Shengguang Ding, Qiying Dai, Haitao Huang, Yiming Xu, Chongjun Zhong -- Basic aspects of muscle atrophy. Myofibers / Dragos Cretoiu [and others] -- Muscle mass, quality, and composition changes during atrophy and sarcopenia / Yosuke Yamada -- Muscle changes during atrophy / Adrian Dumitru, Beatrice Mihaela Radu, Mihai Radu, Sanda Maria Cretoiu -- Skeletal muscle damage in intrauterine growth restriction / Leonard Năstase, Dragos Cretoiu, Silvia Maria Stoicescu -- Molecular mechanisms of muscle atrophy. The role of IGF-1 signaling in skeletal muscle atrophy / Louk T. Timmer, Willem M.H. Hoogaars, Richard T. Jaspers -- mTOR signaling pathway and protein synthesis: from training to aging and muscle autophagy / Jocemar Ilha, Caroline Cunha do Espírito-Santo, Gabriel Ribeiro de Freitas -- Past, present, and future perspective of targeting myostatin and related signaling pathways to counteract muscle atrophy / Willem M.H. Hoogaars, Richard T. Jaspers -- Hormones and muscle atrophy / Ana Isabel Martín, Teresa Priego, Asunción López-Calderón -- Ubiquitin-proteasome pathway and muscle atrophy / Rania Khalil -- Noncoding RNAs in muscle atrophy / Yongqin Li, Xiangmin Meng, Guoping Li, Qiulian Zhou, Junjie Xiao -- NF-kB and inflammatory cytokine signalling: role in skeletal muscle atrophy / Anastasia Thoma, Adam P. Lightfoot -- Redox homeostasis in age-related muscle atrophy / Giorgos K. Sakellariou, McDonagh Brian -- Disturbed Ca2+ homeostasis in muscle-wasting disorders / Guillermo Avila -- Muscle atrophy in diseases and aging. Muscle atrophy in cancer / Jian Yang, Richard Y. Cao, Qing Li, Fu Zhu -- The molecular mechanisms and prevention principles of muscle atrophy in aging / Yu Zhang, Xiangbin Pan, Yi Sun, Yong-jian Geng, Xi-Yong Yu, Yangxin Li -- Muscular atrophy in cardiovascular disease / Isadora Rebolho Sisto, Melina Hauck, Rodrigo Della Méa Plentz -- Muscle atrophy in chronic kidney disease / Jociane Schardong, Miriam Allein Zago Marcolino, Rodrigo Della Méa Plentz -- Sarcopenia in liver disease: current evidence and issues to be resolved / Meiyi Song, Lu Xia, Qi Liu, Mengxue Sun, Fei Wang, Changqing Yang
Diagnosis, drugs and promising agents of muscle atrophy. Muscle atrophy measurement as assessment method for low back pain patients / Elżbieta Skorupska -- Drugs of muscle wasting and their therapeutic targets / Kunihiro Sakuma, Akihiko Yamaguchi -- Nutritional support to counteract muscle atrophy / Daniel John Owens -- Nutritional considerations in preventing muscle atrophy / Sanda Maria Cretoiu, Corina Aurelia Zugravu -- Physical exercise for muscle atrophy / Liang Shen, Xiangmin Meng, Zhongrong Zhang, Tianhui Wang -- Treatment strategies of muscle atrophy. To contrast and reverse skeletal muscle atrophy by full-body in-bed gym, a mandatory lifestyle for older olds and borderline mobility-impaired persons / Ugo Carraro, Karma Gava, Alfonc Baba, Andrea Marcante, Francesco Piccione -- Overview of FES-assisted cycling approaches and their benefits on functional rehabilitation and muscle atrophy / Michelle Rabelo [and others] -- To reverse atrophy of human muscles in complete SCI lower motor neuron denervation by home-based functional electrical stimulation / Helmut Kern, Paolo Gargiulo, Amber Pond, Giovanna Albertin, Andrea Marcante, Ugo Carraro -- Preventing muscle atrophy following strokes: a reappraisal / Sunil Munakomi -- Future prospects. Muscle atrophy: present and future / Richard Y. Cao, Jin Li, Qiying Dai, Qing Li, Jian Yang.
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"The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book's fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy"--Publisher's description.