عنوان
پدید آورنده
موضوع
رده
RC682
RC682
کتابخانه
محل استقرار
9789811314292
9789811314308
9811314292
9811314306
9789811314285
9811314284
Heart genomics /
[Book]
Hong Jiang, Ming Liu, editors.
Singapore :
Springer,
2018.
1 online resource
Translational bioinformatics ;
v. 16
Includes bibliographical references.
Intro; Contents; Chapter 1: Genome-Wide Association Studies ofHypertension andSeveral Other Cardiovascular Diseases; 1 Introduction; 2 GWAS Significant Loci; 2.1 Blood Pressure; 2.2 Coronary Artery Disease (CAD); 3 Clinical Implications; 3.1 Hypertension; 3.2 CAD; 4 Perspectives; References; Chapter 2: Cardiac Transcriptome Profile inHeart Diseases; 1 Introduction; 2 Technology Platforms; 2.1 Methods forCardiac Transcriptome; 2.1.1 RNA Sequencing; 2.1.2 Microarray Analysis; 2.1.3 Array RT-qPCR; 2.1.4 Evaluation andComparison; 2.2 Analysis ofTranscriptome Data
2.2 Histone Modification withCVDs2.2.1 Histone Modification withHypoxia andShear Stress; 2.2.2 Histone Modifications withCAD; 2.2.3 Histone Modifications andHF; 2.2.4 Histone Modifications withHypertension andPulmonary Arterial Hypertension (PAH); 2.3 RNA Silencing withCVDs; 2.3.1 miRNAs andCardiac Aging; 2.3.2 miRNAs andHF; 2.3.3 miRNAs asPotential Biomarkers; 3 The Environment, Epigenetics, andCVD Risk; 3.1 Natural Environmental Exposures; 3.2 Personal Environment; 4 Technical Overview ofPlatform Used inEpigenetic Study
2.2.1 De Novo Transcriptome Analysis2.2.2 Transcriptome Analysis withReference Genome; 2.3 Intact Hearts vs. Isolated Cells inCardiac Disease Studies; 3 Developmental Transcriptome Profiles ofCardiac Cells; 3.1 Developmental Transcriptional Profiles ofCardiomyocytes; 3.1.1 The Developmental Spatial Transcriptomes ofCMs; 3.1.2 The Developmental Temporal Transcriptomes ofCMs; 3.1.3 The Noncoding RNAs inCMs; 3.2 Developmental Transcriptional Profiles ofEndothelial Cells; 3.2.1 The Developmental Temporal Transcriptomes ofECs; 3.2.2 The Function-Related Gene Expression inECs
3.2.3 Gene Expression inECs that Participate inthePathogenesis ofAtherosclerosis3.2.4 The Noncoding RNAs inECs; 3.3 Developmental Transcriptional Profiles ofFibroblasts; 3.3.1 The Function-Related Gene Expression inCFs; 3.3.2 The Noncoding RNAs inCFs; 4 Transcriptomics-Based Biomarkers inTypical Heart Disease; 4.1 Coronary Artery Disease (CAD); 4.1.1 Traditional Biomarkers ofMI; 4.1.2 Message RNAs Implicated inthePrediction andDetection ofMI; 4.1.3 MiRNAs andLncRNAs asDiagnostic Tools inCAD; 4.2 Congestive Heart Failure; 4.2.1 Blood-Based Biomarkers inCHF
4.2.2 Expression Profiling ofHuman Cardiac Tissues inCHF4.2.3 CHF Related Noncoding RNAs; 4.3 Congenital Heart Disease; 4.3.1 Expression Profiling ofCHD; 4.3.2 MicroRNAs inCHD; References; Chapter 3: The Emerging Role ofEpigenetics; 1 Introduction; 1.1 Cardiovascular Diseases; 1.2 Epigenetics; 1.3 DNA Methylation; 1.4 Histone Modifications; 1.5 Noncoding RNAs; 2 Epigenetics andDiseases; 2.1 DNA Methylation andDiseases; 2.1.1 DNA Methylation andCancer; 2.1.2 DNA Methylation andAtherosclerosis; 2.1.3 DNA Methylation withCardiovascular Risk andDiseases
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This book elucidates how advances in genomics research are being applied in connection with heart diseases. It describes the development of genome-scale technologies and their applications to all areas of cardiac investigations, such as genomics, functional genomics, epigenomics, etc., and how they relate to a series of important breakthroughs in various heart diseases. Applying unbiased genomics, combined with a disease-focused and hypothesis-driven approach, represents a promising way to advance our understanding of cardiac diseases. The book offers an important reference work on introducing genomics in heart disease for all scientists and graduate students whose work involves genomics and cardiology, as well as for clinical physicians.
Springer Nature
com.springer.onix.9789811314292
Heart genomics.
9789811314285
Genomics-- Research.
Heart-- Diseases-- Genetic aspects.
Medical genetics.
Cardiovascular medicine.
HEALTH & FITNESS-- Diseases-- General.
Heart-- Diseases-- Genetic aspects.
MEDICAL-- Clinical Medicine.
MEDICAL-- Diseases.
MEDICAL-- Evidence-Based Medicine.
Medical genetics.
Medical genetics.
MEDICAL-- Internal Medicine.
Medical research.
HEA-- 039000
MED-- 014000
MED-- 022000
MED-- 045000
MED-- 112000
MFN
MFN
616
.
1/2
23
RC682
Jiang, Hong
Liu, Ming
20200823224840.0
pn
مطالعه متن کتاب [Book]
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