عنوان

Advances in membrane proteins.

9789811305313

9789811305320

9811305315

9811305323

9789811305313

Advances in membrane proteins.

[Book]

Yu Cao, editor.

Part I,dollar5Mass processing and transportation /

Singapore :

Springer,

2018.

1 online resource (v, 181 pages) :

illustrations (some color)

Intro; Contents; Chapter 1: Membrane AstheBarrier ofLife; 1.1 Peripheral Membrane Proteins (PMPs); 1.2 Integral Membrane Proteins (IMPs); 1.3 Single-Pass Transmembrane Proteins (SPMPs); 1.3.1 Type ITransmembrane Proteins; 1.3.2 Type II Transmembrane Proteins; 1.3.3 Type III & IV Transmembrane Proteins; 1.4 Multiple-Pass Transmembrane Proteins (MPMPs); 1.4.1 Introduction; 1.4.2 The Structural Organization ofMPMPs; 1.4.3 The Functions ofMPMPs; References; Chapter 2: Ion Channels; 2.1 Introduction; 2.1.1 Ion Channel Basics; 2.1.2 Methods ofStudying Ion Channel Function.

2.1.3 Molecular Understanding ofIon Channels2.2 Tetrameric Cation Channel Superfamily; 2.2.1 Introduction; 2.2.2 The Potassium Channel Family asRepresentative; 2.2.3 The Pore Domain: Selectivity Filter andGate; 2.2.4 Molecular Basis ofGating Mechanisms; 2.3 Store-Operated Ca2+ Channels; 2.3.1 Introduction; 2.3.2 Molecular Identification oftheStore-Operated CRAC Channel; 2.3.3 Function oftheCRAC Channel: STIM andOrai; 2.3.4 Structure oftheCRAC Channel Orai; 2.3.5 CRAC Channelopathies andDisease-Causing Mutations inOrai; References.

3.3.7 Flippase Activity ofP4-ATPases andtheir Substrate Specificity3.3.8 Regulation ofP4-ATPases Activity; 3.3.9 Potential Mechanisms ofPhospholipid Translocation byP4-ATPases; 3.4 Floppases; 3.4.1 ATP-Binding Cassette (ABC) Transporters; 3.4.2 Eukaryotic ABC Transporters asPhospholipid Floppases; 3.4.3 Transport Mechanism ofEukaryotic ABC Transporters andFloppases; 3.5 Scramblases; 3.5.1 Scramblases inEukaryotic Cells; 3.5.2 Scramblases Involved inER Membrane Balance; 3.5.3 Scramblases Involved inBlood Coagulation; 3.5.4 Scramblases Involved inApoptosis.

3.5.5 Potential Mechanism ofPhospholipid Scrambling byScramblases3.6 Concluding Remarks; References; Chapter 4: Membrane Phospholipid Biosynthesis inBacteria; 4.1 Introduction; 4.2 Phospholipid Biosynthesis; 4.2.1 LysoPA; 4.2.1.1 The PlsB Pathway; 4.2.1.2 The PlsX/PlsY Pathway; 4.2.1.3 The Fak/PlsY Pathway; 4.2.2 PA; 4.2.2.1 PlsC; 4.2.2.2 DgkA; 4.2.2.3 DgkB; 4.2.3 The Synthesis ofCDP-DAG by CdsA; 4.2.4 Synthesis ofPhosphatidylglycerol Phosphate by PgsA; 4.2.5 The PGP Phosphatases; 4.2.5.1 PgpA; 4.2.5.2 PgpB; 4.2.5.3 PgpC; 4.2.6 The Synthesis ofPS by PssA.

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The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. The first volume focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes. Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization.

Springer Nature

com.springer.onix.9789811305320

9789811305313

Mass processing and transportation

Membrane proteins.

Membrane Proteins.

Life Sciences.

Pharmaceutical Sciences/Technology.

Protein Science.

Protein Structure.

Membrane proteins.

SCIENCE-- Life Sciences-- Biochemistry.

PSBC

SCI-- 007000

Cao, Yu, (Of Shanghai Jiao Tong University School of Medicine)

20200823223855.0

pn

[Book]

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