عنوان

Test No. 412: Subacute Inhalation Toxicity: 28-Day Study /

9264070788

9789264070783

Test No. 412: Subacute Inhalation Toxicity: 28-Day Study /

[Book]

Organisation for Economic Co-operation and Development.

[Paris] :

OECD Publishing,

2009.

1 online resource (14 pages)

OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects,

2074-5788

This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicityby the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk assessments. Groups of at least 5 male and 5 female rodents are exposed 6 hours per day for 28 days to a) the test article at three or more concentration levels, b) filtered air (negative control), and/or c) the vehicle (vehicle control). Animals are generally exposed 5 days per week but exposure for 7 days per week is also allowed. Males and females arealways tested, but they may be exposed at different concentration levels if it is known that one sex ismore susceptible to a given test article. This guideline allows the study director the flexibility toinclude satellite (reversibility) groups, bronchoalveolar lavage (BAL), neurologic tests, and additionalclinical pathology and histopathological evaluations in order to better characterize the toxicity of a testarticle.

Essai n⁰ 412 : Toxicité subaigüe par inhalation : étude sur 28 jours

9789264070790

Chemical tests and reagents.

Chemical tests and reagents.

Organisation for Economic Co-operation and Development.

20200823214252.0

pn

[Book]

Y