عنوان

Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants /

020371198X

1351361724

1351361732

1351361740

9780203711989

9781351361729

9781351361736

9781351361743

1138105910

9781138105911

9781138560185

Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants /

[Book]

editors, James B. Knaak, Howard I. Maibach.

First edition.

Boca Raton, FL :

CRC Press,

2017.

1 online resource :

text file, PDF

CRC Press Revivals

Cover; Title Page; Copyright Page; PREFACE; Contents; SECTION 1: PHARMACOKINETCS, METABOLISM, AND PERCUTANEOUS PENETRATION OF THE SKIN; Chapter 1 Physiologically Based Pharmacokinetic Modeling to Predict Tissue Dose and Cholinesterase Inhibition in Workers Exposed to Organophosphorus and Carbamate Pesticides; Chapter 2 The Application of Pharmacokinetic Models to Predict Target Dose; Chapter 3 Cytochrome P450-Dependent Metabolism of Drugs and Carcinogens in Skin; Chapter 4 Percutaneous Absorption; Chapter 5 In Vitro Skin Metabolism; Chapter 6 Animal Models for Percutaneous Absorption.

Chapter 13 Acute Toxicity Testing by the Dermal RouteChapter 14 Subchronic Dermal Exposure Studies with Industrial Chemicals; Chapter 15 The Dose Response of Percutaneous Absorption; Chapter 16 Reproductive and Developmental Toxicity Studies by Cutaneous Administration; Chapter 17 Dermal Carcinogenicity Studies of Petroleum-Derived Materials; Chapter 18 Comparison of Results from Carcinogenicity Tests of Two Halogenated Compounds by Oral, Dermal, and Inhalation Routes; Chapter 19 The Objectives and Goals of Dermal Carcinogenicity Testing of Petroleum Liquids.

Chapter 20 Chemical Carcinogenesis in Skin: Causation, Mechanism, and Role of OncogenesSECTION 3: DOSE, TOXICITY, AND RISK ASSESSMENT; Chapter 21 Incorporating Biological Information into the Assessment of Cancer Risk to Humans Under Various Exposure Conditions and Issues Related to High Background Tumor Incidence Rates; Chapter 22 Phototoxicity of Topical and Systemic Agents; Chapter 23 Techniques for Assessing the Health Risks of Dermal Contact with Chemicals in the Environment; Chapter 24 Interspecies Extrapolation of Toxicological Data; SECTION 4: NEW MODELS IN SKIN RESEARCH.

Chapter 25 Human Skin Xenografts to Athymic Rodents as a System to Study Toxins Delivered to or Through the SkinChapter 26 The Isolated Perfused Porcine Skin Flap; SECTION 5: EPIDEMIOLOGIC STUDIES OF ROUTE OF EXPOSURE AND HEALTH EFFECTS; Chapter 27 Perspectives on Assessment of Risk From Dermal Exposure to Polycyclic Aromatic Hydrocarbons; Chapter 28 The Paradox of Herbicide 2,4-D Epidemiology; Chapter 29 A Review of Epidemiologic Studies with Regard to Routes of Exposure to Toxicants; Index.

Chapter 7 A Comparative Study of the Kinetics and Bioavailability of Pure and Soil-Absorbed Benzene, Toluene, and m-Xylene after Dermal ExposureChapter 8 Prediction of Human Percutaneous Absorption with Physicochemical Data; Chapter 9 Dermal Absorption of TCDD: Effect of Age; Chapter 10 Percutaneous Absorption of Chemicals from Water during Swimming and Bathing; Chapter 11 Percutaneous Absorption of Contaminants from Soil; SECTION 2: ROUTE OF EXPOSURE AND TOXICOLOGIAL RESPONSE; Chapter 12 General Overview on Toxicological Responses and Routes of Chemical Exposure.

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"Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students."--Provided by publisher.

Ingram Content Group

9781351361736

9781351361736

Dermatotoxicology.

Gases, Asphyxiating and poisonous-- Toxicology.

Dermatotoxicology.

Gases, Asphyxiating and poisonous-- Toxicology.

HEALTH & FITNESS-- Diseases-- General.

MEDICAL-- Clinical Medicine.

MEDICAL-- Diseases.

MEDICAL-- Evidence-Based Medicine.

MEDICAL-- Internal Medicine.

HEA-- 039000

MED-- 014000

MED-- 022000

MED-- 045000

MED-- 112000

MED017000

MED096000

SCI026000

Wang, Rhoda G. M.

Knaak, James B.

Maibach, Howard I.

20200822093843.0

pn

[Book]

Y