عنوان

Damage-associated molecular patterns in human diseases.

3030087565

3319786555

3319786563

9783030087562

9783319786551

9783319786568

3319786547

9783319786544

Damage-associated molecular patterns in human diseases.

[Book]

Walter Gottlieb Land.

Volume 1,dollar5Injury-induced innate immune responses /

Cham, Switzerland :

Springer,

2018.

1 online resource (xlviii, 870 pages) :

illustrations (some color)

Includes bibliographical references.

Intro; Foreword; Reference; Preface; Acknowledgments; Contents; Abbreviations; Part I: The Three Major Paradigms in Modern Immunology; 1: Prologue: The Term "Immunity" over the Course of Time; 1.1 When It All Began; 1.2 Metchnikoff's Cellular Theory of Host Defense; 1.3 Ehrlich's and von Behring's Humoral Theory of Host Defense; 1.4 Outlook; References; 2: The Three Major Paradigms in Immunology; 2.1 Introduction; 2.2 Burnet's Self/Nonself Discrimination: Clonal Selection Theory; 2.3 Janeway's Pattern Recognition Theory; 2.4 The Danger/Injury Theory; 2.4.1 Introductory Remarks

2.4.2 Land's Injury Theory2.4.3 Matzinger's Danger Theory; 2.4.4 The Evolution of the Danger/Injury Model; 2.5 Outlook; References; 3: Epilogue: What Major Paradigm in Immunology Comes Next?; Part II: The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis; 4: Prologue: The Guardians of Homeostasis; 4.1 Introduction; 4.2 Systemic Homeostasis-Tissue Homeostasis-Cellular Homeostasis; 4.3 The Four Major Systems of Homeostasis Surveillance; 4.4 Outlook: The Innate Immune System as an Organ of Perception; References; 5: Innate Immune Recognition Molecules

5.1 Introduction5.2 The "Classical" Cell-Associated Pattern Recognition Receptors; 5.2.1 Introductory Remarks; 5.2.2 Toll-Like Receptors; 5.2.2.1 General Remarks; 5.2.2.2 The Family of Toll-Like Receptors and Their Structure; 5.2.2.3 Toll-Like Receptors at the Plasma Membrane; 5.2.2.4 Toll-Like Receptors at the Endosomal Membranes; 5.2.2.5 Toll-Like Receptor Signalling; 5.2.2.6 Concluding Remarks; 5.2.3 Nucleotide-Binding Oligomerization Domain-Like Receptors; 5.2.3.1 General Remarks; 5.2.3.2 The Family of NOD-Like Receptors and Their Structure

5.2.3.3 Inflammasome-Forming NOD-Like ReceptorsNLRP3 Inflammasome; The NLRP1 Inflammasome; The NLRP6 and NLRP7 Inflammasomes; The NLRP12 Inflammasome; The NLRC4 Inflammasome; 5.2.3.4 Non-inflammasome-Forming NOD-Like Receptors; NOD1/NOD2; NLRP10; NLRX1 and NLRC5; MHC Class II Transactivator; 5.2.3.5 Concluding Remarks; 5.2.4 Helicase Retinoic Acid-Inducible Gene I-Like Receptors; 5.2.4.1 General Remarks; 5.2.4.2 The Family of RIG-I-Like Receptors and Their Structure; 5.2.4.3 RIG-I-Like Receptor Signalling; 5.2.4.4 Concluding Remarks; 5.2.5 Absent in Melanoma 2-Like Receptors

5.2.5.1 General Remarks5.2.5.2 The Family of AIM2-Like Receptors, Their Structure, and Inflammasome Formation; 5.2.5.3 Concluding Remarks; 5.2.6 Other Cytosolic DNA-Sensing Receptors; 5.2.6.1 General Remarks; 5.2.6.2 Cyclic GMP-AMP Synthase: An Important DNA Receptor; 5.2.6.3 Further DNA-Sensing Receptors; 5.2.6.4 DNA-Sensing Receptors Initiating the DNA Damage Response; 5.2.6.5 Concluding Remarks; 5.2.7 C-Type Lectin Receptors; 5.2.7.1 General Remarks; 5.2.7.2 Dectin-1 and Dectin-2; 5.2.7.3 LOX-1, MGL, Mincle, DNGR-1, and MICL; 5.2.7.4 The DC-SIGN Receptor

0

8

8

8

8

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

Springer Nature

com.springer.onix.9783319786551

9783319786544

9783319786568

Injury-induced innate immune responses

Immunology.

Wounds and injuries-- Immunological aspects.

Wounds and Injuries-- immunology.

Allergies.

Clinical & internal medicine.

Immunology.

Immunology.

Medical-- Immunology.

Medical-- Internal Medicine.

Medical research.

Science-- Life Sciences-- Biology-- Molecular Biology.

MED045000

MJ

MJ

Land, Walter Gottlieb

20200823113615.0

pn

[Book]

Y