Intro; Foreword; Preface; Contents; Contributors; Chapter 1: Prostate Cancer Screening in African-ƯAmerican Men; Diagnosis and Screening; Evaluation; Management; Conclusion; References; Chapter 2: Evaluation and Treatment for Older Men with Elevated PSA; PSA Screening and USPSTF Recommendations; Impact of USPSTF Recommendations; Overdiagnosis and Overtreatment; Life Expectancy Tools; Assessment of Cancer Risk; Alternatives to PSA-Based Screening: Biomarkers; PSA Derivatives; Free PSA; Prostate Health Index; 4Kscore; Prostate Cancer Antigen 3; Predictive Nomograms; Prostate MRI.
Benign Prostate TissuePSA Bounce; Biochemical Recurrence Definition; Historical/Alternative Criteria; Phoenix Criteria; Evaluation; Sites of Recurrence; Traditional Evaluation; Imaging Evaluation; Bone Imaging; CT Scan/MRI; Role of Biopsy; Emerging/Advanced Imaging; Therapeutic Management; Localized Salvage Treatment; Considerations; Observation; Salvage Prostatectomy; Salvage Radiation; Salvage Cryoablation; Salvage HIFU; Distant Salvage Treatment; Treatment of Oligometastatic Disease with Radiation or Surgical Excision; Systemic Treatment Options; Androgen Deprivation Therapy; Conclusion.
Pre-prostatectomy Patient EvaluationPost-prostatectomy Patient Evaluation; Post-prostatectomy Radiation Therapy; Adjuvant Radiation Therapy; Salvage Radiation Therapy; Selective Treatment Intensification with Post-prostatectomy Radiation Therapy; Future Directions; Conclusions and Recommendations for Presented Clinical Case; References; Chapter 8: Biochemical Recurrence After Radiation Therapy; Screening/Surveillance; Recurrence Risk; Concurrent Androgen Deprivation Therapy; PSA Kinetics; Disease-Specific Risk; Surveillance Schedule; Diagnosis; Variation Between Radiation and Surgery.
Should African American Men Be Eligible for Active Surveillance?Considerations for Choosing Active Surveillance; Conclusions; References; Chapter 5: Focal Therapy Versus Surveillance in Intermediate-Risk Cancer; Screening; Diagnosis; Evaluation; Therapeutic Management; Active Surveillance; Focal Therapy; Conclusions; References; Chapter 6: Prostate Cancer Treatment Options for Men with Significant Urinary Symptoms and Enlarged Prostates; Evaluation; Therapeutic Management; Conclusion; References; Chapter 7: Adjuvant Radiation Therapy for High-ƯRisk Post-prostatectomy Patients.
Special Considerations in Elderly PatientsAn Optimized Diagnostic Approach; Conclusions; References; Chapter 3: Utilizing Biomarkers in Patients with Prior Negative Prostate Biopsy; Current Clinical Information; Free PSA; Prostate Health Index; Kallikrein Panel (4Kscore); Prostate Cancer Antigen 3 (PCA3); DNA Methylation Assays (ConfirmMDx); Current Guidelines and Future Directions; Summary; References; Chapter 4: Active Surveillance in African-Americans; Evaluation and Guidelines; Racial Differences in Prostate Cancer Burden and Mortality.
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This book provides a single, comprehensive reference source that incorporates all the latest information regarding prostate cancer. It serves as an easy reference source for researchers, clinicians, individuals in training, allied health professionals and medical students regarding prostate cancer by focusing on the controversial points of debate. New data regarding PSA screening, prostate cancer biomarkers, diagnostic evaluation techniques, surveillance protocols, and treatment interventions for localized and more advanced disease are discussed, and gaps in current knowledge and areas for future research are highlighted. Ongoing important clinical trials are also discussed. This text is organized around defined clinical scenarios which are encountered routinely by physicians who care for patients with prostate cancer. The case based format permits presentation of information of concise practical significance. The chapters run the gamut from screening controversies, utility of biomarkers, surveillance strategies, and innovative treatment. The text incorporates key educational concepts in the framework of patient situations with evidence-based discussions of screening, diagnosis, evaluation, and therapeutic management. It also features a comment section from leaders in the field that will be more "opinion-based" allowing the reader to get access to experienced physicians' thought processes and practice patterns. Prostate Cancer: Clinical Case Scenarios will quickly become the ready reference source for professionals and students in various fields with an interest in the management of a complex and multifaceted disease such as prostate cancer.