عنوان

RNA metabolism in mitochondria /

3030086372

3319781901

331978191X

9783030086374

9783319781907

9783319781914

3319781898

9783319781891

RNA metabolism in mitochondria /

[Book]

Jorge Cruz-Reyes, Michael W. Gray, editors.

Cham :

Springer,

2018.

1 online resource (ix, 249 pages) :

illustrations (some color)

Nucleic Acids and Molecular Biology,

volume 34

0933-1891 ;

Includes bibliographical references.

The mitochondrial transcription machinery -- Mitochondrial RNA turnover in Metazoa -- Mitochondrial RNase P complex in animals: mitochondrial tRNA processing and links to disease -- Intercompartment RNA trafficking in mitochondrial function and communication -- Control mechanisms of the holo-editosome in trypanosomes -- Mitochondrial RNA editing and processing in diplonemid protists -- Mechanisms and evolution of tRNA 52 editing in mitochondria -- Editing of mitochondrial RNAs in Physarum polycephalum -- Requirement of various protein combinations for each C-to-U RNA editosome in plant organelles.

0

This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 52 and 32 ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.

Springer Nature

com.springer.onix.9783319781907

9783319781891

Mitochondria.

RNA-- Metabolism.

Mitochondria.

RNA-- metabolism.

Biochemistry.

Medical genetics.

Microbiology (non-medical)

Mitochondria.

RNA-- Metabolism.

SCIENCE-- Life Sciences-- Biochemistry.

PSB

PSB

SCI-- 007000

Cruz-Reyes, Jorge

Gray, Michael W.

20200823113040.0

pn

[Book]

Y