Intro; Foreword; Preface; Acknowledgments; Contents; Contributors; 1: MOSS: A Patient-Centered Approach; Background; Historical Approaches; MOSS, A Patient-Centered Approach to Metastatic Disease of the Spine; Medical/Mental Component; Oncologic Component; Stenosis (Ambulatory/Neurologic) Component; Stability Component; Summary; Application of MOSS: Three Case Reports; Case 1; Case 2; Case 3; References; 2: Relative Radiosensitivity of Metastatic Spine Disease; References; 3: Relative Chemo-, Hormonal, and Immunosensitivity; Introduction; Assessing Response to Treatment; Tissue Procurement.
Magnetic ResonanceClassification Systems; Denis; Taneichi; Asdourian; White and Panjabi; SINS; References; 6: Imaging Metastatic Spinal Disease; Background; Imaging Considerations; Radiography; Computed Tomography; Magnetic Resonance Imaging; Bone Scintigraphy; Positron-Emission Tomography; Approach to Evaluating the Spine; Illustrative Cases in Diagnostic Imaging; Case 1; Case 2; Case 3; Case 4; Case 5; Case 6; Case 7; Case 8; Case 9; References; 7: Management of Metastatic Spinal Cord Compression Without Stereotactic Radiotherapy and Targeted Adjuvant Chemotherapy; Introduction.
Role of Spine Surgery in Metastatic Spinal Cord Compression TreatmentThe Role of Minimally Invasive (MI) Techniques in MESCC; Decision-Making in Case of Metastatic Spinal Cord Compression; Flow Chart for Multidisciplinary Management of Metastases in the Mobile Spine; Experience at Our Institution; Materials and Methods; Results; References; 8: Metastatic Spine Disease: Critical Evaluation of the Current Literature; Introduction; Steroids; Radiotherapy; Stereotactic Radiosurgery; Surgery; Treatment Framework; References; 9: Indications for En Bloc Spondylectomy for Metastatic Spine Disease.
Variability of SensitivityBreast Cancer; Lung Cancer; Prostate Cancer; Renal Cell Carcinoma; Lymphoma; Myeloma; Sarcoma; Bone Antiresorptive Therapy; References; 4: NOMS; NOMS Framework; Neurologic; Oncologic; Radiation; Chemotherapy and Immunotherapy; Mechanical; Systemic; Surgical Considerations; Separation Surgery; Surgical Stabilization; Case Illustrations; Case #1 Fig. 4.3; Case #2 Fig. 4.4; References; 5: Spinal Instability in Metastatic Disease; Introduction; Initial Evaluation; Clinical Evaluation; Radiographic Evaluation; Plain Radiographs; Nuclear Medicine Scans; Computed Tomography.
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This comprehensive text focuses exclusively on the management of metastatic spinal disease, evaluating the most recent literature and providing patient-centered treatment algorithms. Beginning with initial imaging, classification and clinical decision-making, the spine is approached anatomically from the upper cervical to the sacrum, describing the unique considerations and approaches appropriate to each region, such as laminectomy and stabilization, en bloc spondylectomy and resection and reconstruction. Less invasive and minimally invasive approaches are discussed throughout the text. Radiation therapy modalities and other adjuvant treatments are also discussed, as well as reconstructive flap coverage and the management of complications. The spinal column is the most common site of metastatic cancer, and a multidisciplinary approach is required to provide patients with reasonable management options to prevent and treat the disabling symptoms caused by this debilitating condition. This compendium of experience from thought leaders in the treatment of metastatic spine disease will provide spine surgeons, oncologists, radiation oncologists, physiatrists and palliative care specialists with up-to-date information to guide their patients through the multidisciplinary management of metastatic spinal disease.