Intro; Preface; Contents; Part I: Evolution and Biology of the Skeleton; 1: Evolution of the Skeleton; 1.1 From the Primeval Sea to the Precambrian Period; 1.2 The "Cambrian Explosion"; 1.3 Development of the External Skeleton; 1.4 Development of the Internal Skeleton; 1.5 Calcium Phosphate: The New Building Material; 1.6 Development of the Backbone; 1.7 Invasion of the Dry Land; 1.8 Bone and Blood Formation; 1.9 The Human Skeleton; 2: Structure and Architecture of Bone; 2.1 Function of the Skeleton; 2.2 Architecture of Bone; 2.3 Blood Vessels and Nerves of Bone and Marrow.
3: Modelling and Remodelling of Bone3.1 Bone Cells; 3.2 Bone Remodelling Units; 4: Control and Regulation of Bone Remodelling; 4.1 Mechanisms Regulating Bone Mass; 4.2 Osteoimmunology; 4.3 RANK/RANKL/Osteoprotegerin System; 4.4 Leptin; 5: Growth and Ageing of Bone; 5.1 Types of Ossification; 5.2 Growth of the Embryo in the Uterus; 5.3 Peak Bone Mass; Part II: Diagnostic Tools in Bone Disorders; 6: Clinical Evaluation; 6.1 Age and Location; 6.2 Bone Pain; 6.3 Swelling and Deformity of Bone; 6.4 Systemic Signs and Basic Systemic Diseases; 7: Skeletal Radiology.
7.1 Imaging Techniques7.1.1 Conventional X-Ray; 7.1.2 Computed Tomography (CT); 7.1.3 Magnetic Resonance Imaging (MRI); 7.1.4 Nuclear Medical Examination Techniques; 7.1.5 Bone Densitometry; 7.2 Aspects of Imaging of Selected Tissue Disorders; 7.2.1 Fractures; 7.2.2 Osteoporosis; 7.2.3 Other Systemic Bone Diseases; 7.2.3.1 Osteomalacia and Rickets; 7.2.3.2 Hyperparathyroidism; 7.2.3.3 DISH (Diffuse Idiopathic Skeletal Hyperostosis); 7.2.3.4 SAPHO Syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis); 7.2.3.5 CRMO; 7.2.4 Local Bone Disease; 7.2.4.1 Osteomyelitis.
7.2.4.2 Paget's Disease7.2.4.3 Bone Marrow Oedema; 7.2.4.4 Osteonecrosis, Bone Infarcts; 7.2.4.5 Soft Tissue Calcification; 7.2.5 Bone and Bone Marrow; 7.2.5.1 Myelogenous Osteopathies; 7.2.5.2 Storage Diseases; 7.2.5.3 Lymphomas; 7.2.5.4 Multiple Myeloma; 7.2.5.5 Systemic Mastocytosis; 7.2.6 Bone and Joints; 7.2.6.1 Degenerative Joint Diseases; Osteoarthritis; Osteochondrosis; 7.2.6.2 Chronic Polyarthritis; 7.2.6.3 Seronegative Spondyloarthritis/Ankylosing Spondylitis; 7.2.6.4 Infectious Spondylitis/Spondylodiscitis; 7.2.7 Bone and Tumour.
7.2.7.1 General Diagnostic Approach for Tumours in the Peripheral Skeleton7.2.7.2 Bone Metastases; 8: Bone Densitometry; 8.1 Methods for Measurement; 8.2 Skeletal Sites of Measurement; 8.3 Indications for Measurement; 8.4 Exposure to Radiation; 9: Laboratory Investigations; 9.1 Recommended Tests; 9.2 Significance of Markers of Bone Turnover; 10: Bone and Bone Marrow Biopsy; 10.1 Potential of Bone Biopsy in Clinical Practice; 10.2 Biopsy Sites; 10.3 Biopsy Needles and Electric Drill; 10.4 Biopsy Evaluation; 10.5 Indications for Taking a Bone Biopsy.
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This comprehensive manual covers all aspects of the prevention, diagnosis and management of osteoporosis, offering an upbeat and optimistic assessment of what can be achieved. While scientifically based, the book provides easy-to-follow guidelines for lifelong maintenance of skeletal structure and function. It deals with everything from the basic physiology of bone and mineral metabolism to the diagnostic utility of radiologic imaging and specialized tests and current treatment recommendations, including for fracture management. The relationship of osteoporosis to a variety of other disorders is also thoroughly explored and elucidated. Osteoporosis represents a global threat because every human being is vulnerable to it as time passes. The authors point out the enormous scale of the problem in terms of the human suffering, morbidity, and mortality on the one hand and the associated astronomical national and global costs on the other. Osteoporosis is preventable, and every doctor in every medical discipline can contribute to this goal. And though prevention is better than cure, it is never too late for effective therapy, as outlined in this book. Bone is every doctorʼs and every bodyʼs business!