Intro; Preface; Contents; Contributors; Chapter 1: An Introduction to Drug Testing: The Expanding Role of Mass Spectrometry; 1 Introduction; 2 Therapeutic Drug Monitoring; 3 Toxicology; 4 Evaluation of Methods; 5 Quality Assurance; 6 Conclusions; References; Chapter 2: Quantification of Eight Cannabinoids Including Cannabidiol in Human Urine Via Liquid Chromatography Tandem Mass Spe ... ; 1 Introduction; 2 Materials; 2.1 Supplies and Equipment; 2.2 Cannabinoid Calibrator and Quality Control Solutions; 2.3 Solutions and Buffers; 3 Methods; 3.1 Sample Preparation
2.1 Supplies and Equipment2.2 Standards and Controls; 2.3 Solutions; 3 Methods; 3.1 Sample Preparation; 3.2 Analysis; 4 Notes; References; Chapter 9: Analysis of Tryptic Peptides from Therapeutic Monoclonal Antibodies Using LC-MS/MS; 1 Introduction; 1.1 Tryptic Peptide Methods; 2 Materials; 2.1 Reagents and Mobile Phases; 2.2 Standards and Controls; 2.3 Supplies and Instrumentation; 3 Methods; 3.1 Saturated Ammonium Sulfate Extraction; 3.2 Trypsin Digestion; 3.3 LC-MS/MS Set-Up and Quantitation of Infliximab; 4 Notes; References
2.2 Standards and Controls2.3 Supplies and Equipment; 3 Methods; 3.1 Extraction Procedure (see Note 3); 3.2 Analysis; 4 Notes; References; Chapter 5: Measurement of Buprenorphine and Norbuprenorphine in Urine; 1 Introduction; 2 Materials; 2.1 Prepared Reagents (See Note 1); 2.2 Preparation of Urine Calibrators and Controls; 2.3 Supplies and Analytical Equipment; 3 Method; 3.1 Sample Preparation; 3.2 Analysis; 4 Notes; References; Chapter 6: Quantitation of Tapentadol by Liquid Chromatography: Tandem Mass Spectrometry; 1 Introduction; 2 Materials; 2.1 Solvents (See Note 1)
2.2 Supplies and Equipment3 Methods; 3.1 Preparation of Working Standards and Unknown Samples; 3.2 Analysis; 4 Notes; References; Chapter 7: Therapeutic Drug Monitoring of Lacosamide by LC-MS/MS; 1 Introduction; 2 Materials; 2.1 Internal Standard, Calibrators, Controls, and Buffers; 2.2 Supplies and Analytic Equipment; 3 Methods; 3.1 Extraction of Lacosamide from Plasma and Serum; 3.2 LC-MS/MS Analysis; 3.3 Data Analysis; 4 Notes; References; Chapter 8: LC-MS/MS Method for the Quantification of the Leflunomide Metabolite, Teriflunomide, in Human Serum/Plasma; 1 Introduction; 2 Materials
3.2 Liquid Chromatography Tandem Mass Spectrometry Analysis4 Notes; References; Chapter 3: Analysis of Benzodiazepines for Drug-Facilitated Assaults and Abuse Settings (Urine); 1 Introduction; 1.1 Benzodiazepines and Their Analogs; 1.2 Overview of Published Methods; 2 Materials; 2.1 Solutions and Reagents (See Note 5); 2.2 Supplies and Equipment; 3 Methods; 3.1 Sample Analysis; 3.2 Analysis; 4 Notes; References; Chapter 4: Targeted Opioid Screening Assay for Pain Management Using High-Resolution Mass Spectrometry; 1 Introduction; 2 Materials; 2.1 Samples and Reagents