عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
TL49797
انگلیسی
Comparative Studies on Biochemical and Pharmacological Profiles of Bovine, Ovine and Porcine Heparins
[Thesis]
Ahmed Kouta
Fareed, Jawed
Loyola University Chicago
2017
180
Place of publication: United States, Ann Arbor; ISBN=978-0-355-66540-6
M.S.
Pharmacology & Experimental Therapeutics
Loyola University Chicago
2017
Heparin, a highly sulfated glycosaminoglycan (GAG), is used extensively as an anticoagulant. It consists of repeating disaccharide units, containing iduronic acid (or glucuronic acid) and glucosamine, exhibiting variable degrees of sulfation. Heparin, and its analogues, are used during surgery and dialysis, and are often used to coat indwelling catheters and other devices where the vascular system is exposed. Administered parenterally, often continuously due to its short half-life, over 0.5 billion doses are required per year. Heparin is currently obtained from mucosal tissue of meat animals, mainly porcine intestine, and to a lesser extent bovine and ovine sources. The early stages of production are poorly controlled, due to the source of the material. This problem came into sharp focus in 2008 when the presence of contaminating over-sulfated chondroitin sulfate in heparin sourced from China resulted in almost 100 deaths in the USA. Coupled with the fact that only a few doses are obtained from each animal and due to cultural and religious reasons in some countries, alternative and well controlled sources of heparins are needed. The FDA and other regulatory agencies are currently considering the introduction of bovine and ovine unfractionated heparins. Worldwide, there are 1.4 billion cattle, 1.9 billion sheep and goats and 980 million pigs. Both cow and sheep provide potential alternate sources of porcine heparin. Nowadays, with the advances in technology and manufacturing processes, higher quality bovine and ovine heparins are now available in various part of the world and have been shown to exhibit similar biologic and clinical profiles compared to porcine one.
Pharmacology
Health and environmental sciences
Luchsinger, Alexander
Fareed, Jawed
Pharmacology & Experimental Therapeutics
Loyola University Chicago
2018397147; 10637299
مطالعه متن کتاب p
[Thesis]
276903
a
Y
