عنوان

Identification of Genetic Factors in the Etiology of Autism Spectrum Disorder in Arab Families

TL49387

انگلیسی

Identification of Genetic Factors in the Etiology of Autism Spectrum Disorder in Arab Families

[Thesis]

Yasser Ammar  AlSarraj

El-Agnaf, Omar M.; El-Shanti, Hatem

Hamad Bin Khalifa University (Qatar)

2017

61

Committee members: Abdelalim, Essam M.; Akaaboune, Mohammed; Al Thani, Dena A.

Place of publication: United States, Ann Arbor; ISBN=978-1-369-80566-6

M.S.

Science and Engineering

Hamad Bin Khalifa University (Qatar)

2017

Autism spectrum disorder (ASD) is a social interaction and communication impairment, associated with repetitive behaviors and interests. ASD has a high worldwide prevalence of about 1-1.5%. ASD is usually accompanied with heterogeneous phenotypic comorbidities, such as epilepsy and intellectual disability (ID). Twin studies suggest a high genetic contribution to ASD etiology, and several well-known rare genetic disorders are associated with ASD with high susceptibility contribution risk at about 0.5-1% of ASD cases. Moreover, several environmental factors and chromosomal abnormalities may increase the risk; the estimated known ASD-related genetic etiology is identifiable in about 25% of all ASD cases. Nevertheless, in about 75% of ASD cases the genetic etiologies remain elusive. The occurrence of ASD in the Middle East is not clear and there is a need to fill the gap in its clinical and genetic characterization in the Arab populations.

Genetics; Bioinformatics

Biological sciences;ASD;Autism;Whole Exome Sequencing

Elbelazi, Samah A.

El-Agnaf, Omar M.; El-Shanti, Hatem

Science and Engineering

Hamad Bin Khalifa University (Qatar)

1909332738; 10285241

p

[Thesis]

276903

a

Y