عنوان

The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction

9780120224777

b606521

The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction

[Book]

S Celeste Posey Morley

The adaptive immune system is regulated in large part by the CD4 + helper T lymphocytes. Antigen-presenting cells (APCs) display peptide antigens in the context of major histocompatibility complex (MHC) molecules on their surface that can bind to the T cell receptor (TCR) on antigen-specific T cells. When bound, the TCR complex generates a complicated array of intracellular signals. The integrated outcome of these signals depends on the cellular context in which the signal is received and may result in T cell activation, anergy, or apoptosis. A signal is generated when a peptide in the context of an MHC molecule engages the TCR complex. This binding interaction sets off a cascade of membrane proximal events in T cell signal transduction that include activation (or inactivation) of enzymes (kinases and/or phosphatases), phosphorylation of substrates, and recruitment of adapter proteins that enable the formation of large signaling complexes. These early signaling events of tyrosine phosphorylation and protein-protein interactions enable the propagation of downstream signals that lead to calcium flux and the activation of downstream kinases, such as mitogen-activated protein kinases (MAPK).

S Celeste Posey Morley

Barbara E Bierer Affiliation: Department of Pediatrics, Harvard Medical School, Boston, Massachusetts USA

S Celeste Posey Morley

[Book]

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