عنوان

Amyloid and Amyloidosis 1990

9401132844

9789401132848

b595192

Amyloid and Amyloidosis 1990

[Book]

edited by Jacob B. Natvig, Øystein Førre, Gunnar Husby, Anne Husebekk, Bjørn Skogen, Knut Sletten, Per Westermark.

Dordrecht

Springer Netherlands

1991

(968 pages)

Transplantation.- Differential Influence of Glucocorticoids on CRP and SAA Serum Levels in Rheumatoid Arthritis and Polymyalgia Rheumatica.- Ocular Microangiopathy in Familial Amyloidotic Polyneuropathy (FAP) Type I.- Spectral Analysis of R-R Variability in Familial Amyloidotic Polyneuropaty, Andrade Type.- Microalbuminuria in Patients with Familial Mediterranean Fever.- Dopamine-ss-Hydroxylase in Familial Mediterranean Fever.- A Multicentric Study on Hemodialysis Amyloid Osteoarthoropathy in 747 Dialysis Patients.- Renal Transplantation in Renal Amyloid end-Stage Disease.- Effect of Continuous Colchicine Treatment in Familial Mediterranean Fever (FMF).- Treatment of Amyloidosis Associated Diarrhea with a Somatostatin Analogue.- Gastrointestinal Malabsorption in Familial Amyloidotic Polyneuropathy (FAP): Ursodeoxycolic Acid Absorption Test.- The Prevalence, Importance and Significance of Amyloidosis with Rheumatic Diseases in Turkey.- Cyclosporin Reduces the Incidence of Amyloid Disease in Casein Treated Mice.- X Special Session on Bio Assays and Standardization of Amyloid Proteins and Precursors.- Report of Special Session on Bioassays and Standardization of Amyloid Proteins and Precursors.- Identification of APO-SAA Isoforms in Man and Mouse.- Normal Lipoproteins Inhibit Binding of SAA-Rich Lipoproteins to Polyvinylchloride Surfaces.- Monoclonal Antibody Based Elisa for Human SAA.- Serum Amyloid P Component in Chronic Renal Failure and Dialysis.- Monoclonal Antibodies to Human Serum Amyloid P-Component.- Screening with Monoclonal Anti ss-Protein Antibody for Immunoreactivity in the Sera of Patients with Alzheimer's Disease.- XI Summary Sessions.- Summary Of Day 1: Overview.- Summary of Day 2: Amyloidosis: Molecular Insights and Cellular Blindspots.- Summary of Day 3: Overview.- List of Contributors.

Increased Frequency in Patients with Congestive Cardiac Failure.- Characterization of Molecular forms of Calcitonin in Amyloid Fibrils from Medullary Carcinoma of the Thyroid.- VI Patho-Fibrillogenesis and Amyloid Proteins.- Pathofibrillogenesis and Amyloid Proteins.- The Sulphate and Chloride Ions have Different Effects on the Structure of AA Amyloid Fibrils.- Kinetic Properties of Amyloid Fibril Polymerization in Vitro.- In Vitro Assembly of Murine Amyloid a Protein, Two Murine Serum Amyloid a Proteins, and Normal Human Transthyretin to form Amyloid-Like Fibrils.- Secondary Structure Changes in Mutant Transthyretins After Proteolysis by Neutrophilic Serine Proteases.- Production of Amyloidogenetic Peptides from Human Immunoglobulin Light (L)-Chains.- Predominance of One SAA Isotype (SAAI) in Human Reactive Amyloid.- A Histochemical Model of the Amyloid Fibril.- High Molecular Weight Proteins, Sensitive to Collagenase Digestion are Intimate Constituents of Amyloid Deposits.- Intraperitoneal Amyloid Formation by Amyloid Enhancing Factor Rich Macrophages in Ascitic Fluid.- Histochemically Recognizable Changes of Amyloid Fibrillogenic Macrophages.- Ultrastructural Aspects of Cell Membrane in AA-Amyloidogenesis.- Amyloid Fibril Formation in the Rough Endoplasmic Reticulum of Plasma Cells from a Patient with Localized A? Amyloidosis.- A Comparative Study of Amyloid Formation and Resorption Using Immunoelectron Microscopy.- A Histochemical, Immunohistochemical, Ultrastructural and Immunoelectron Microscopical Characterization of Cerebrovascular Amyloid and Diffuse Plaques in Autopsied Aged Dogs.- Increased Binding of Acute Phase Lipoproteins by Peritoneal Macrophages (MOS) in Mice.- Characterization of Non-AA Proteins in Amyloid Fibrils Obtained from a Cow With Chronic Infection.- Compositional Analyses of Amyloid Fibrils.- Intratumour Amyloidosis in Primary and Metastatic Nasopharyngeal Carcinoma: an Immunohistochemical and Ultrastructural Study.- Intratumour Amyloidosis in Carcinoma of the Cervix.- VII Transthyretin Related Amyloid and Hereditary Amyloidosis.- Molecular Biology of Amyloidogenesis in the Transthyretin Related Amyloidosis.- Studies on the Molecular Arrangement in Transthyretin-Related Familial Amyloidotic Polyneuropathy Fibrils.- X-Ray Crystal Structure of the Met-30 Variant of Human Prealbumin (Transthyretin).- Disulfide Bond Formation of Transthyretin (TTR) As Possible Initial Step of Familial Amyloid Polyneuropathy (FAP).- Structure of Transthyretin Molecules in Amyloid Fibrills from the Vitreous Body in Individuals with the Met30 Mutation.- Formation of Fibrils by Normal Transthyretin and Synthetic Transthyretin Fragments In Vitro.- First Turkish Family with FAP has Homozygous Met 30 Ttr.- A New Transthyretin Variant Associated with Familial Amyloidotic Polyneuropathy in an Italian Kindred.- Clinical Characterization of a New TTR Variant in an Italian Family: TTR Ala 49.- A TTR Acidic Variant Dna Analysis of Homozygous and Heterozygous Individuals.- Asn 90 is the Variant TTR in An Italian Fap Kinship.- Frequency of the Position 122 (Val?Ile) Variant Transthyretin Gene in Blacks without Amyloidosis.- Variant Transthyretins in Familial Amyloidotic Polyneuropathy (FAP).- Three Novel Variants of Transthyretin Identified in Three Japanese Kindreds with Familial Amyloidotic Polyneuropathy.- A Possible New Transthyretin Genetic Variant in a Family with Cardiac Amyloidosis.- Structural Studies of Transthyretin and Related Fragments Obtained from a Swedish Patient (V-AS 280) with Senile Systemic Amyloidosis.- The Transthyretin cDNA Sequence is Normal in Transthyretin-Derived Senile Systemic Amyloidosis.- A Recombinant System for Production of Variant Type Human Transthyretin(TTR).- Assessement of Structure and Binding Capacities of Secreted Mutant Transthyretins by an E.Coli System.- Structure and Function of Recombinant Human Transthyretin.- Detection of Variant Transthyretin Genes by Restriction Analysis of PCR-Amplified Genomic Dna.- Myelin P2 Protein in Transthyretin (Ser-84) Vitreous Amyloid.- Cloning and Trimming of the TTR-Cdna Gene by PCR.- Pathological Similarity of Transgenic Mice Carrying the Human Mutant Transthyretin Gene to Human Familial Amyloidotic Polyneuropathy (FAP) Type I.- Prealbumin Type Cerebral Amyloid Angiopathy in Familial Amyloid Polyneuropathy.- Amyloid Localized to the Tenosynovium at Carpal Tunnel Release: Immunohistochemical Identification of Amyloid Type.- Reevaluation of 134 Patients with Familial Amyloidotic Polyneuropathy (FAP) in Japan, Kumamoto Focus.- Sympathetic Skin Response in Familial Amyloid Polyneuropathy.- Extrinsic and Intrinsic Nerve Lesions of the Intestine in Type I Familial Amyloid Polyneuropathy.- Sex Differences and Age-Dependent Penetrance in Fap-Type I.- Parental Transmission and Age-of-Onset in Familial Amyloidotic Polineuropathy (Portuguese Type).- Anticipation of Age-of-Onset in Familial Amyloidotic Polineuropathy (Portuguese Type).- Sporadic, Late-Onset Case of Familial Amyloid Polyneuropathy Type I (Andrade) - A Clinicopathological Study.- Familial Amyloidosis without Transthyretin (TTR) Involvement: an Unusual Presentation.- VIII Amyloid in Alzheimer's Disease.- Mechanisms of Amyloid Fibril Formation in Alzheimer's Disease and Other Dementias.- Amyloid ss-Protein Deposition as a Seminal Pathogenetic Event in Alzheimer's Disease.- Proteolytic Processing of ss-Amyloid Protein-Related Synthetic Peptides and the ss-Protein Precursor by a Protease Purified from Alzheimer's Disease Brain.- Immunoreactivity of Alzheimer Amyloid Precursor Protein (APP) Specific Antisera with Platelet Granule Constituents.- Site of Formation of ss-Protein Amyloid Fibrils.- A Search for Vascular Amyloid Using A4 Amyloid Antibody Immunostain in CAA (Classic Methods) Negative Alzheimer's Cases.- A Variant of Gerstmann-Straussler-Scheinker Disease with ss-Protein Epitopes and Dystrophic Neurites in the Peripheral Regions of Prp-Immunoreactive Amyloid Plaques.- Antigenic Heterogeneity of Cerebral Amyloid Deposits in Alzheimer'S Disease.- Systemic Vascular Amyloidosis Associated with Alzheimer's Disease.- Pathological Changes in Hereditary Cerebral Hemorrhage with Amyloidosis - Dutch Type.- Hereditary Cerebral Hemorrhage with Amyloidosis - Dutch Type.- Peripheral Distribution of Dermatan Sulfate Proteoglycan (Decorin) in Amyloid Plaques and Their Presence in Neurofibrillary Tangles of Alzheimer's Disease.- Choroid Plexus Amyloid.- IX Diagnostics, Clinical and Therapeutic Aspects.- New Images of Clinical Amyloidosis.- Scintigraphic Imaging of Amyloidosis with 123Iodine Serum Amyloid P Component.- Longtime Follow Up of Patients with Al-Amyloidosis with MRI.- Detection of Autonomic Dysfunctions in Patients with Familial Amyloidotic Polyneuropathy (FAP) by Laser Doppler Method.- Non-Invasive in vivo Detection of Ab-Amyloidosis Using its Radiolabelled Precursor Protein.- Cardiac Involvement in Secondary Amyloidosis.- Imaging Hereditary Amyloidosis of Ostertag.- Computer-Aided Immunohistochemical Quantitation of Amyloid in Renal Biopsies.- Abdominal Fat Biopsy for Characterization of the Major Amyloid Fibril Proteins by Amino Acid Sequence Analysis.- Beta-2-Microglobulin Does Not Deposit in Abdominal fat Tissue of Long-Term Hemodialysis Patients.- Histopathologic Classification, Clinical Characteristics and Survival of 18 Patients with Inconclusive Clinical Data to Identify the AA Or Al Type of Their Systemic Amyloidosis.- Immunohistochemical Detection of Amyloid AA in Formaline-Fixed Paraffine-Embedded Rectal Biopsies with the Monoclonal Anti-Human SAA Antibody Reu.86.2.- Long Survival in Patients with Al Amyloidosis.- Secondary Systemic Amyloidosis (AA): Response and Survival in 64 Patients.- Renal Manifestations of Amyloidosis Complicated with Rheumatoid Arthritis.- Crp and SAA Serum Levels In Chronic Active Hepatitis.- Serum Amyloid a and C-Reactive Protein in the First 4 Weeks After Liver

Partial Amino Acid Sequence Analysis of an Equine Immunoglobulin-Lambda Light Chain.- Experimental Amyloid Casts in Mice Induced by Injection of a Human Bence Jones Protein.- III Amyloid Enhancing Factor (AEF), Amyloid P-Component and Proteoglycans in Amyloidosis.- Common Elements in Amyloidosis.- Metabolic Studies of Radioiodinated Serum Amyloid P Component in Normal Subjects and Patients with Systemic Amyloidosis.- Structural and Functional Studies of Serum Amyloid P Component.- Quantification of Amyloid P-Component in Multiple Tissues of Patients with Primary and Familial Amyloidosis.- A Primed State Exists in Vivo Following Regression of Murine AA Amyloidosis.- Serum Amyloid P-Component (SAP) Regulation by Sex-Steroids in Rats: Compared with C-Reactive Protein (CRP).- Acute Phase Protein Response to Collagen Induced Arthritis in Mice.- An Attempt to Study the Role of Serum Amyloid P Component in the Formation of Amyloid Deposits in a Transgenic Mouse Model of Familial Amyloidotic Polyneuropathy.- Differential Regulation of Sap Gene Expression in Syrian and Armenian Hamsters.- Isolation of cDNA Clones and Expression Analyses for Rat Serum Amyloid P (SAP) Component.- Isolation of a 16 KD Fraction with Extremely High AEF Activity.- Amyloid Enhancing Factor (AEF) - Induced Amyloidosis Lacks Inflammatory Reaction.- The Tissue Origin of Amyloid Enhancing Factor Determines its Ability to Induce SAA Gene Expression.- Pmsf-Sensitive Serine Esterase-Activity and Fibril-Derived Amyloid Enhancing Factor (FAEF)-Activity in Hamster are Not Related.- Induction of Amyloid Deposition by Subfractions of the Amyloid Enhancing Factor Extracted from Brain of Patients with Alzheimer's Disease.- Isolation of Amyloid Enhancing Factor (AEF).- Effects of Amyloid Enhancing Factor on in Vitro Kupffer Cells.- Macromolecular Characteristics of AA Type Amyloid Associated Polysaccharides from Human Liver, Kidney and Spleen with AA Amyloid Secondary to Rheumatic Disease.- Heparan Sulfate Accumulation in the ss-Amyloid Protein Containing Lesions of Down's Syndrome Occurs Prior to the Appearance of Fibrillar Amyloid.- Rapid Synthesis of cRNA Probes for SAA, SAP and Heparan Sulfate Proteoglycan Mrnas by Transcription of Polymerase Chain Reaction Generated Templates.- Basement Membrane Components in Addition to HSPG are Present in Murine AA Amyloid Deposits.- The Basement Membrane form of Heparan Sulphate Proteoglycan is Part of Human IAPP Amyloid Deposits in the Islets of Langerhans.- Isolation and Characterisation of the Integral Glycosaminoglycan Constituents of Human AA And Al Amyloid Fibrils.- Basement Membrane Components and Protein AA in Renal Amyloid Deposits.- High Molecular Weight Polysaccharides in Familial Cardiac Amyloid of Danish Origin Related to Transthyretin Met 111.- IV Cystatin C, ss-2 Microglobulin, APO AI and APO All Related Amyloidoses.- Point Mutation in Autosomal Dominant forms of Amyloidosis.- Perturbation of Processing of Cystatin C in Monocytes from Patients with Hereditary Cystatin C Amyloid Angiopathy.- Molecular Biology of Hereditary Cystatin C Amyloid Angiopathy in Iceland.- Cerebral Amyloid Angiopathy Associated with Cerebral Hemorrhage with the Deposition of Cystatin C: Study on Japanese Cases.- Several ss2-Microglobulin Fragments Identified in An Amyloidoma in A Patient with Long-Term Hemodialysis.- Clinical Evaluation of Osteoarthropathy in 43 Patients on Hemodialysis, Using Cuprophane Membranes for ? 5 Years.- ss2-Microglobulin-Derived Amyloid and Calcium in Long-Term Dialysis Patients.- In Vivo Metabolism of A Mutant Apolipoprotein A-I (Arg-26) Associated with Hereditary Amyloidosis.- New Usa Family Has Apolipoprotein A1 (ARG26) Variant.- Molecular Genetic Study of Mouse Senile Amyloidosis.- Fluorometric Examination of Tissue Amyloid Fibrils in Murine Senile Amyloidosis: Use of the Fluorescent Indicator, Thioflavine T.- The Low Leukocyte (LLC) Mouse, A Second Model of "Senescence Accelerated" Amyloidosis Associated with Apolipoprotein All Pro5 ? Gln; Prevalence of this Substitution Among Inbred Strains of Mice.- Age-Related Amyloid in the Aorta.- Complete Primary Structure of Amyloid Protein in Finnish Hereditary Amyloidosis. Identification of a New Type of Amyloid Protein Derived from Variant (Asn-187) Gelsolin.- Polymerization of Gelsolin Variant Fragment in Tissue Causes Familial Amyloidosis, Finnish Type (FAF).- Gelsolin-Related Amyloidosis. Immunohistochemical Studies in Finnish Hereditary Amyloidosis with Antibodies to a Synthetic Dodecapeptide of the Amyloidogenetic Region of Gelsolin.- Familial Amyloidosis, Finnish Type.- Shared Gelsolin Antigenicity Between Familial Amyloidosis Finnish Type (FAF) and One form of Familial Lattice Corneal Dystrophy (LCD) with Polyneuropathy from the United States.- V Amyloid Proteins Related to Polypeptide Hormones.- Polypeptide Hormones and Amyloid.- Islet Amyloid Polypeptide (IAPP): Structure of its cDNA and Gene and the Identification of Species Differences of Importance for Islet Amyloid Formation.- Human Islet Amyloid Polypeptide (IAPP): Identification in Human Pancreas, Establishment of Radioimmunoassay, and its Response to Physiological Stimulation.- Rat Islet Amyloid Polypeptide (IAPP): Isolation and Sequence Determination, Immunohistochemical Study, and its Secretion from Pancreas.- Factors Affecting Diabetogenesis and Amyloidogenesis are Provided by Studies of IAPP in the Dog and Cat.- Islet Amyloid Polypeptide: Synthetic Peptides for Study of the Pathogenesis of Islet Amyloid.- Intracellular Formation of Amyloid Fibrils in B-Cells of Human Insulinoma and Pre-Diabetic Monkey Islets.- A Comparative Study Between Human B-Cell Insulin and Islet Amyloid Polypeptide (IAPP) Storage and Amyloid Deposition in Type 2 Diabetes Mellitus And in Non-Diabetics.- Pancreatic Islet Amyloid in the Degu is Derived from Insulin.- Isolated Atrial Amyloid Deposits. Immunochemical Evidence for the Presence of Polypeptides with Molecular Weights Higher and Lower Than Atrial Natriuretic Peptide (ANP).- Raised Prevalence of Isolated Atrial Amyloidosis in Chronic Heart Disease.- Isolated Atrial Amyloidosis.

Welcome.- Elliott F. Osserman In Memoriam.- The 1990 Guidelines for Nomenclature and Classification of Amyloid and Amyloidosis.- I Protein Aa/Saa and Secondary Amyloidosis.- The Human Saa Genes and Their Regulation by Cytokines.- Genetic Isofocusing Variant of Human Serum Amyloid A.- Sequence Analysis of a Third Human Saa Gene.- Human Serum Amyloid-A Protein: Variability Demonstrated by Cdna Sequencing and Expression Studies.- Abyssinian Cat Model of Aa Amyloidosis: Saa Gene Analysis.- Mink Serum Amyloid a Protein - Expression and Primary Structure of Amyloidogenic and Non-Amyloidogenic Isotypes.- Primary Structure of Two Rabbit Serum Amyloid a Proteins (Saa) Based on Cdna Sequence.- Biosynthesis and Processing of Saa by Mouse L-Cells Transfected with the Human Saag9 Gene.- Regulation of Serum Amyloid a (Saa) Synthesis in Hep 3B Cells by Cytokines and Corticosteroids.- Regulation of Saa Synthesis by Cytokines in a Human Hepatoma Cell Line.- Saa Secretion from Cytokine-Stimulated Human Hepatoma Cells Requires Hdl.- Interferon a Induces Tnf Elevations in Vivo. Correlation with Other Acute Phase React Ants.- Acute Phase Protein, Serum Amyloid a, Inhibits Il-1- and Tnf-Induced Fever and Hypothalamic Pge2 In Mice.- Human Recombinant TNF-? and Poly I. Poly C Induce Saa and Enhance Amyloidosis in Hamster.- The Physiology of the Acute Phase Serum Amyloid a (Saa) Response in Mice.- Mouse Saa3: Detection in Mouse Tissues with Specific Antibody.- Generation and Use of Site-Specific Antibodies Against Saa.- The N-Terminus is the Lipid-Binding Site of Saa: Supporting Evidence by Moabs.- Epitope Mapping of Amyloid-a Protein Using Monoclonal Antibodies.- Reactive (Aa) Amyloidosis in a 14 Year Old with No Predisposing Disease.- Induction of Amyloidosis in Mice: Preparation of Active Azocasein (Azo) and Effect of Endotoxin (Lps).- Serum Amyloid a (SAA) Induction in the Serum High Density Lipoproteins of the Syrian Hamster.- The Complete Primary Structure of Bovine Serum Amyloid Protein a (SAA) and of Tissue Amyloid Fibril Protein a (AA) Subspecies.- Degradation of Saa in Amyloid Fibrils by Elastase.- Evolutionary Aspects of Protein Saa.- Strain Specific Variation in Expression of Novel Mouse Apo-Saa Isoforms.- Saa Isotypes in Patients with Secondary Amyloidosis.- Differential Regulation of Human Serum Amyloid a Isoforms.- The Effect of SAA-Derived Fragment - SAA2-82 - On Platelet Aggregation.- Serum Amyloid a, An Acute Phase Protein, Inhibits Platelet Activation.- Serum Amyloid a (SAA)-Related Peptide Isolated from Synovial Fluid Modulates Superoxide Production by Human Neutrophils.- Antiplatelet Aggregation Activity of Serum Amyloid a (SAA) Related Peptides.- Effect of Purified Serum Amyloid a on Growth and Differentiation of Transformed Cells.- II Al Protein and Light Chain Related Amyloidosis.- Primary Systemic Amyloidosis (AL) In 1990.- Comparison of the Amino Acid Sequences of Ten Kappa I Amyloid Proteins for Amyloidogenic Sequences.- Characterization of a X Al Protein and Two Amyloidgenic X Bjp in Three Cases of Immunoglobulin Amyloidosis.- Biclonality in Amyloidosis Patient Mal: One Clone Producing an Amyloidogenic, the Other a Non-Amyloidogenic Kappa L-Chain.- Complete Amino-Acid Sequence of a Kappa Light Chain Fragment Isolated from the Urine of Amyloidosis Patient Mal.- Comparative Studies of Two al Chains of Kappa-III Light Chain Origin with and Without Attached Carbohydrate (Al So124 and Al 700).- Structural Studies of two Carbohydrate-Containing Al Chains (?II) Al NoV and Al Mc.- Complete Amino-Acid Sequence of Al-Bence-Jones Protein Pol of the Lambda I Subclass.- Complete Amino-Acid Sequence of Al-Lambda 1.1 Bence-Jones Protein Ezi.- Complete Amino Acid Sequence of A A Amyloid Fibril Protein Isolated from the Liver of Amyloidosis Patient Dia.- Systemic Al Amyloidosis In A Cat.- Experimental Production of Human Amyloidosis Al.- Al Amyloid, L-Chain and L&H-Chain Deposition Diseases: Comparison of Ig Synthesis and Tissue Deposition.- Gene Rearrangement Studies in the Diagnosis of 'Primary' Systemic Amyloidosis and Nodular Localized Cutaneous Amyloidosis.- Clinicopathologic Correlations in 109 Patients with Systemic Amyloidosis Studied by Immunocytochemistry.- Quantification of Non-Light Chain Amyloid Precursors and Acute Phase-Related Proteins in Al-Amyloid Sera.- Incidence and Epidemiology of Primary Systemic Amyloidosis (AL) in Olmsted County, Minnesota: 1950 Through 1989.- Low Incidence of Al Amyloidosis in Japan.- Clinical Indications of Systemic Amyloidosis in Myeloma Patients.- Bence Jones Proteinemia Without Bence Jones Proteinuria in Al Amyloidosis.- Systemic Amyloidosis and Monoclonal Gammopathy in Three Italian Siblings: a Familian Case of Al-Amyloidosis?.- Primary Systemic Amyloidosis (Al): a Randomized Trial of Colchicine Vs. Melphalan And Prednisone Vs. Melphalan, Prednisone, and Colchicine.- Response Rates and Survival in Primary Systemic Amyloidosis.- Urinary Protein Patterns Predict Survival in Primary Systemic Amyloidosis (Al).- ss2-Microglobulin Predicts Survival in Primary Systemic Amyloidosis (AL).- Cutaneous Amyloidosis in a Horse.

Proceedings of the VIth International Symposium on Amyloidosis, held in Oslo, Norway, 5-8 August 1990

Cardiology.

Medicine.

Nephrology.

edited by Jacob B. Natvig, Øystein Førre, Gunnar Husby, Anne Husebekk, Bjørn Skogen, Knut Sletten, Per Westermark.

Anne Husebekk

Bjørn Skogen

Gunnar Husby

Jacob B Natvig

Knut Sletten

Øystein Førre

Per Westermark

[Book]

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