عنوان

Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance :

8847020859

9788847020856

b591247

Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance :

[Book]

From Basic to Clinical Research

edited by Eugenio E. Müller.

Milano

Springer Milan

2003

(xii, 197 pages)

LHRH/Somatostatin --; Chapter1 Twenty-five Years of Endocrine Oncology with Analogs of Hypothalamic Peptides: an Overview --; Chapter2 Analogs of Luteinizing Hormone-releasing Hormone in Benign Prostatic Hyperplasia and Advanced Renal Cell Carcinoma --; Chapter3 Luteinizing Hormone-releasing Hormone Antagonists in Gynecology --; Chapter4 Physiology and Pharmacology of Somatostatin and Its Receptors --; Chapter5 Investigation of LHRH Receptor Involvement in Melanoma Growth and Progression --; Somatostatin/GHRH/GH --; Chapter6 Cortistatin: Not Simply a Natural Somatostatin Analogue --; Chapter7 Antineoplastic and Antiangiogenic Actions of Somatostatin Analogs --; Chapter8 Somatostatin in Clinical Endocrinology --; Chapter9 Antagonists of Growth Hormone-releasing Hormone in Oncology --; Chapter10 GH Receptor Antagonists: Basic Knowledge and Clinical Perspectives --; Ghrelin and Ghrelin Mimetics (GHS) --; Chapter11 Hypothalamic Circuits Responsive to Ghrelin: Regulation by Leptin and Insulin --; Chapter12 Physiological Function of Growth Hormone Secretagogue Receptors in the Cardiovascular System --; Chapter13 Endocrine and Extraendocrine Activity of Ghrelin and the GHS: Basic Research --; Chapter14 Endocrine and Nonendocrine Actions of Ghrelin and GHS: State of the Art in Clinical Research --; Hormonal Treatments for Endocrine-Dependent Tumors --; Chapter15 Hormonal Treatments of Endocrine-Dependent Tumors: Preclinical Aspects --; Chapter16 Hormonal Treatment of Endocrine-Dependent Tumors: Clinical Considerations --; Chapter17 Letrozole in the Treatment of Advanced Breast Cancer.

The book describes the ability of a series of endocrine-derived compounds, i.e. CHRH, LHRH, somatostatin, anti-androgens, and aromatase inhibitors to exert a direct anti-neoplastic activity or to potentiate the activity of traditional chemotherapeutic agents on neuroendocrine and solid tumors. In addition, a new class of potent GH-releasers, GSHs/Ghrelin, endowed with important endocrine and extra-endcocrine action, is presented. Therefore, in addition to traditional chemotherapy, characterized by high toxicity and non-selective action on tumoral cells, the reader can find a new approach with more selective, less cytotoxic endocrine derived compounds.

Endocrinology.

Medicine.

Oncology.

edited by Eugenio E. Müller.

Eugenio E Müller

[Book]

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