عنوان

Plant bioactive compounds for pancreatic cancer prevention and treatment

1634633571

9781634633574

b582749

Plant bioactive compounds for pancreatic cancer prevention and treatment

[Book]

Christopher J. Scarlett and Quan V. Vuong, editors.

New York

Nova Publishers

©2015.

Cancer etiology, diagnosis, and treatments.

Includes index.

PLANT BIOACTIVE COMPOUNDS FOR PANCREATIC CANCER PREVENTION AND TREATMENT; PLANT BIOACTIVE COMPOUNDS FOR PANCREATIC CANCER PREVENTION AND TREATMENT; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: Pancreatic Cancer: Challenges for Therapeutic Development; Abstract; 1. Epidemiology and Aetiology of PDAC; Epidemiology; Aetiology and Risk Factors; Non-modifiable Risk Factors; Modifiable Risk Factors; Familial Predisposition; 2. Diagnosis and Challenges in Early Diagnosis; Diagnosis; Challenges in Early Diagnosis and Screening. 3. Challenges in Therapeutic DevelopmentSurgery Is Safer, but Still Under-Utilised; Advances and Challenges in Multimodality Therapy; 4. PDAC as a Systemic Disease; 5. Therapeutic Development in PDAC; 6. PDAC Is a Heterogeneous Disease; Pancreatic Cancer Genomes; 7. Challenges Moving Forward; 8. Advancing Molecular Phenotype Guided Therapy; Rationalise Existing; Gemcitabine; DNA-Damaging Agents; Abraxane®; Erlotinib; Rescuing Failed Therapeutics; HER2 Amplification/Herceptin®; Smoothened Inhibitor Responsiveness; Repurposing Existing Therapeutics; mTOR Inhibitor Responsiveness. Novel/Pre-clinicalConclusion; References; Chapter 2: History and Development of Plant-Derived Anti-Cancer Agents; Abstract; 1. Introduction; 2. Clinically Established Plant-Derived Anti-Cancer Agents; 2.1. Vinca Alkaloids; 2.2. Taxanes; 2.3. Podophyllotoxin Analogs; 2.4. Camptothecin Analogs; 3. Plant-Derived Anti-Cancer Agents Used in the Treatment of Pancreatic Cancer; 3.1. Irinotecan; 3.2. Taxanes; 3.3. Minnelide; Conclusion; References; Chapter 3: Traditional Use of Plants As Folk Medicine; Abstract; 1. Introduction. Global Perspective on Traditional Medicine and Approaches to Cancer Treatments2. Traditional Chinese Medicine (TCM); 3. Ayurveda; 4. Greco-Arabic Traditions; 5. European Traditions; 6. Anthrosophical Medicine; 7. North American Traditions; Original Essiac Formula; Physiomedical and Eclectic Traditions; Hoxsey Formula; 8. Naturopathic Movements and Integrative Health; 9. Exploring Traditional Plant Medicines for Bioactive Leads; 10. The Role of Herbal Remedies As Adjuvants in Conventional Cancer Therapy; Management of Nausea and Vomiting; Radioprotection and Sensitizing with Herbs. 11. The Use of Topical and Eschariotic AgentsConclusion; References; Chapter 4: Bioactive Plants and Health Benefits; Abstract; 1. Introduction; 2. Common Bioactive Compounds in Medicinal Plants; 2.1. Biosynthesis of Plant Compounds; 2.2. Classification of Bioactive Plant Compounds; 2.2.1. Alkaloids; 2.2.2. Terpenoids; 2.2.3. Phenolic Compounds: Phenylpropanoids, Coumarins, Flavonoids and Tannins; 2.2.4. Glycosides; 3. Bioactive Plants and Health Benefits; 3.1. Cancer; 3.2. Cardiovascular Diseases; 3.3. Diabetes; 3.4. HIV/AIDS; 3.5. Malaria; 3.6. Tuberculosis; 3.7. Womens Health.

With the rapid advancements in medical research, diagnostic technology and increased public health initiative and awareness, overall cancer death rates in western societies are declining each year with the number of deaths from major cancers such as breast, colorectal and lung following this trend. However, the survival rate for those with pancreatic cancer has been at a standstill for over four decades and there are concerns that pancreatic cancer may become the second deadliest cancer in the US by the year 2030. The diagnosis of pancreatic cancer has dire consequences as it presents late in.

Pancreas -- Cancer.

Plant bioactive compounds.

SCIENCE -- Life Sciences -- Biochemistry.

Christopher J. Scarlett and Quan V. Vuong, editors.

Christopher J Scarlett

Quan V Vuong

[Book]

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