PrefaceContributorsIntroductionAn Overview of Adaptive Randomization Designs in Clinical TrialsOleksandr SverdlovRestricted RandomizationEfron's Biased Coin Design Revisited: Statistical Properties, Randomization-Based Inference, and Sequential MonitoringVictoria PlamadealaAdaptive Biased Coins: Achieving Better Balance without Compromising RandomnessAlessandro Baldi Antognini and Maroussa ZagoraiouBrick Tunnel and Wide Brick Tunnel Randomization for Studies with Unequal AllocationOlga M. Kuznetsova and Yevgen TymofyeyevCovariate-Adaptive RandomizationDevelopment of Novel Covariate-Adaptive Randomization DesignsWenle ZhaoOptimal Model-Based Covariate-Adaptive Randomization DesignsAnthony AtkinsonStatistical Inference Following Covariate-Adaptive Randomisation: Recent AdvancesD. Stephen CoadCovariate-Adaptive Randomization with Unequal AllocationOlga M. Kuznetsova and Yevgen TymofyeyevResponse-Adaptive RandomizationOptimal Allocation Designs for a Multi-Arm Multi-Objective Clinical TrialDavid AzrielResponse-Adaptive Randomization: An Overview of Designs and Asymptotic TheoryLi-Xin ZhangStatistical Inference Following Response-Adaptive RandomizationYanqing Yi and Xikui WangSample Size Re-Estimation in Adaptively Randomized Clinical Trials with Missing DataRuitao Lin and Guosheng YinSome Caveats for Outcome Adaptive Randomization in Clinical TrialsPeter F. Thall, Patricia S. Fox, and J. Kyle WathenCovariate-Adjusted Response-Adaptive RandomizationEfficient and Ethical Adaptive Clinical Trial Designs to Detect Treatment-Covariate InteractionSeung Won Hyun, Tao Huang, and Hongjian ZhuLongitudinal Covariate-Adjusted Response-Adaptive Randomization: Impact of Missing DataTao Huang and Hongjian ZhuTargeted Covariate-Adjusted Response-Adaptive LASSO-Based Randomized Controlled TrialsAntoine Chambaz, Mark J. van der Laan, and Wenjing ZhengCovariate-Balanced Bayesian Adaptive Randomization: Achieving Tradeoff Between Inferential and Ethical Goals in Small and Moderate Size TrialsYing Yuan and Jing NingRandomized Designs with Treatment SelectionMulti-Arm Multi-Stage Designs for Clinical Trials with Treatment SelectionJames WasonSequential Elimination in Multi-Arm Selection TrialsChristina Yap, Xuejing Lin, and Ying Kuen K. CheungAccounting for Parameter Uncertainty in Two-Stage Designs for Phase II Dose-Response StudiesEmma McCallum and Bjoern BornkampApplication and Practical AspectsA Single Pivotal Adaptive Trial in Infants with Proliferating Hemangioma: Rationale, Design Challenges, Experience, and RecommendationsStephane Heritier, Caroline C. Morgan-Bouniol, Serigne N. Lo, Stephanie Gautier, and Jean Jacques VoisardPractical Implementation of Dose-Response Adaptive TrialsTom Parke and Martin KimberStatistical Monitoring of Data in Response-Adaptive Randomized Clinical TrialsPaul Gallo