عنوان

Biological response modifiers :

3642785492

9783642785498

b573843

Biological response modifiers :

[Book]

interferons, double-stranded RNA, and 2',5'-oligoadenylates

W.E.G. Müller, H.C. Schröder (eds.).

Berlin ; New York

Springer-Verlag

©1994.

(xiv, 275 pages) : illustrations

Progress in molecular and subcellular biology, 14.

Activation of the dsRNA-dependent kinase / R.A. Petryshyn [and others] --; Double-stranded RNAs as gene activators / S. Landolfo [and others] --; Viral-dependent phosphorylation of a dsNRA-dependent kinase / D.A. Roth and X. He --; Cellular inhibitors of the interferon-induced, dsRNA-activated protein kinase / T.G. Lee and M.G. Katze --; Mechanisms of the antiretroviral effect of dsRNA / W.E.G. Müller [and others] --; The antiviral activity of RNA-dye combinations / J.M. Jamison [and others] --; Chemical synthesis of 2',5'-oligoadenylate analogues / R. Charubala and W. Pfleiderer --; Homologies between different forms of 2-5A synthetases / E. Truve, [et al.] --; 2-5A and virus infection / N. Fujii --; The 2-5A system and HIV infection / H.C. Schröder, [et al.] --; 2',5'-oligoadenylate synthetase in autoimmune BB rats / V. Bonnevie-Nielsen --; Oligoadenylate and cyclic AMP : interrelation and mutual regulation / A.V. Itkes --; Regulation of HIV replication in monocytes by interferon J.A. Turpin, [et al.] --; Transmembrane signaling by IFN-[alpha] / L.M. Pfeffer, [et al.] --; Photolabeling of the enzymes of the 2-5A synthetase/RNase L/p68 kinase antiviral systems with azido probes / R.J. Suhadolnik.

Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.

Biological response modifiers.

Protein-Serine-Threonine Kinases -- metabolism.

RNA, Double-Stranded -- genetics.

W.E.G. Müller, H.C. Schröder (eds.).

Heinz C Schröder

Werner E G Müller

[Book]

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