عنوان

Benzodiazepines II :

3642740316

9783642740312

b573238

Benzodiazepines II :

[Book]

a Handbook. Basic Data, Analytical Methods, Pharmacokinetics, and Comprehensive Literature

by Harald Schütz.

Berlin, Heidelberg

Springer Berlin Heidelberg

1989

(xiii, 623 pages 183 illustrations)

Index of Treated Substances.- List of Synonyma.- Biotransformation.- Formation of the Hydrolysis Derivatives.- TLC-Data.- Thin-Layer Chromatography - The Concept of the Corrected Rf-Value (Rfc-Value).- Screening of the Benzodiazepines via Rfc-Values.- Screening of the Benzodiazepines via Aminobenzophenones and Bratton-Marshall Detection.- GLC-Data and UV-Spectra.- Gas Chromatography - The Concept of the Retention Index.- List of UV-Maxima.- UV-Spectra (Ultraviolet-Spectra).- List of Important m/z-Values.- Infrared- and Mass-Spectra.- Immunological Methods.- Presentation of Analytical Methods.- Methods for the Determination of New Benzodiazepines.- alprazolam.- brotizolam.- clotiazepam.- delorazepam, chlordesmethyldiazepam.- estazolam.- ethyl loflazepate.- flumazenil, Ro 15-1788.- halazepam.- metaclazepam.- midazolam.- pinazepam.- quazepam.- temazepam.- tetrazepam.- triazolam.- Additional Methods for the Determination of Benzodiazepines Already Described in Vol. I.- Simultaneous Methods.- Mono Methods.- bromazepam.- clobazam.- clonazepam.- diazepam.- flunitrazepam.- flurazepam.- lorazepam.- nitrazepam.- List of Therapeutic and Toxic Concentrations.- Blood-, Serum- and Plasma-Levels and Other Pharmacokinetic Data from Literature.- alprazolam.- brotizolam.- clotiazepam.- delorazepam, chlordesmethyldiazepam.- estazolam.- ethyl loflazepate.- flumazenil, Ro 15-1788.- halazepam.- loprazolam.- metaclazepam.- midazolam.- oxazolam.- pinazepam.- quazepam.- temazepam.- tetrazepam.- triazolam.- Survey of Benzodiazepine Literature.- 1 Absorption Studies.- 2 Analytical Studies.- 3 Antagonist Studies.- 4 Anesthesia Studies.- 5 Behavioral Studies.- 6 Biotransformation/Metabolism.- 7 Casuistics.- 8 Feto-Maternal-Studies.- 9 GABA-Studies.- 10 Galenic Studies.- 11 Gas-Chromatography.- 12 High-Pressure-Liquid-Chromatography.- 13 Hydrolysis Studies.- 14 Immunoassays (RIA, EMIT, TDx and Others).- 15 Interactions.- 16 Mass-Spectrometry.- 17 NMR-Studies.- 18 Pharmacokinetics (Levels).- 19 Pharmacology and Clinical Studies.- 20 Photometry (UV-, IR-, VIS-, Fluorometry).- 21 Polarography.- 22 Protein Binding.- 23 Radioactive-Labelled Compounds.- 24 Radioreceptor Assays.- 25 Receptor Studies.- 26 Review Articles.- 27 Screening Methods.- 28 Side-, Adverse-, Residual-Effects.- 29 Sleep Studies.- 30 Synthesis of Benzodiazepines.- 31 TLC-Studies.- 32 Toxicity.- 33 Miscellaneous.- References.

This completely new volume is a companion to Benzodiazepines by the same editor, which has established itself as a standard work since it appeared in 1982. Benzodiazepines II contains a complete update of information, with new substances as well as new methods of analysis and pharmacokinetics. A comprehensive list of more than 7500 references is a special feature which makes the volume a practical guide for the non-analyst as well. From the reviews of Benzodiazepines: "This publication is valuable as an up-to-date reference work on benzodiazepine literature and on the relevant chemical, analytical and pharmacological data contained therein. It merits a place in the laboratories and libraries of those institutions where analytical, pharmacological, toxicological and clinical investigations are taking place." Analyst#1.

Analytical biochemistry.

Medicine.

Toxicology.

by Harald Schütz.

Harald Schütz

[Book]

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