عنوان

Somatic Diversification of Immune Responses

3540636080

3642719848

9783540636083

9783642719844

b573051

Somatic Diversification of Immune Responses

[Book]

edited by Garnett Kelsoe, Martin F. Flajnik.

Berlin, Heidelberg

Springer Berlin Heidelberg

1998

(x, 221 pages 38 illustrations)

Current topics in microbiology and immunology, 229.

List of Contents --; The Role of Promoter-Intron Interactions in Directing Hypermutation --; Somatic Hypermutation of Immunoglobulin Genes is Linked to Transcription --; On the Possible Role of Natural Reverse Genetics in the V Gene Loci --; Characteristics of Somatic Hypermutation of Human Immunoglobulin Genes --; Antibody Diversification in the Rabbit: Historical and Contemporary Perspectives --; Rabbit Appendix: A Site of Development and Selection of the B Cell Repertoire --; Affinity Maturation of the Primary Response by V Gene Diversification --; Lymphocyte Development and Selection in Germinal Centers --; Somatic Mutagenesis and Evolution of Memory B Cell --; Repertoire Diversification of Primary vs Memory B Cell Subsets --; Plasticity Under Somatic Mutation in Antigen Receptors --; Theoretical Limits to Massive Receptor Editing in Immature B Cells --; Clone: A Monte-Carlo Computer Simulation of B Cell Clonal Expansion, Somatic Mutation, and Antigen-Driven Selection --; Somatic Mutation in Ectothermic Vertebrates: Musings on Selection and Origins.

This volume offers an overview of some important aspects of immune function. V(D)J hypermutation drives the somatic evolution of antigen-reactive B lymphocytes and is necessary for the generation of protective humoral immunity. The mechanism of this hypermutation remains enigmatic, although several seemingly mutually exclusive models have been proposed. Perhaps surprisingly, this volume demonstrates that there is no consensus on the major problems in the area of somatic diversification; the same experimental data has been interpreted in different ways by various authors. This lack of consensus reveals that the field of somatic diversification, from top to bottom, is an exciting area of immunology that stubbornly keeps its secrets to itself.

Cytology.

Immunology.

Medicine.

edited by Garnett Kelsoe, Martin F. Flajnik.

Garnett Kelsoe

M F Flajnik

[Book]

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