عنوان

Ergot Alkaloids and Related Compounds

3642667759

3642667775

9783642667756

9783642667770

b572412

Ergot Alkaloids and Related Compounds

[Book]

edited by B. Berde, H.O. Schild.

Berlin, Heidelberg

Springer Berlin Heidelberg

1978

Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie,, 49.

I Introduction to the Pharmacology of Ergot Alkaloids and Related Compounds as a Basis of Their Therapeutic Application --; II Chemical Background --; A. Occurrence, Biosynthesis, and Production --; B. Structure and Synthesis of the Natural Alkaloids --; C. Chemical Modifications in the Lysergic Acid Half of Ergot Alkaloids --; D. Chemical Modification in the Peptide Part of Ergot Alkaloids --; E. Some Analytical Tools for the Determination of Ergot Alkaloids --; F. Subject Index --; G. References --; III Basic Pharmacological Properties --; A. Introduction --; B. Actions of Ergot Alkaloids at 5-HT Receptors --; C. Actions of Ergot Alkaloids at Dopamine Receptors --; D. Actions of Ergot Alkaloids at Adrenoceptors --; E. The Shape of Ergotamine and Dihydroergotamine in Relation to Their Interaction With?-Adrenoceptors --; F. Actions of Ergot Alkaloids at Acetylcholine Receptors --; G. Actions of Ergot Alkaloids at Histamine Receptors --; H. Interaction of Ergot Alkaloids With Prostaglandins --; J. Stimulation of Smooth Muscle by Ergot Alkaloids Mediated by Miscellaneous Mechanisms --; K. Biochemical Identification of Specific Binding Sites for Ergot Alkaloids --; L. References --; IV Effects on the Uterus --; A. Introduction --; B. Actions on Uterine Motor Activity --; C. References --; V Actions on the Heart and Circulation --; A. Actions on Systemic Blood Pressure --; B. Hemodynamic Effects --; C. Effects on Regional Hemodynamics --; D. Actions on the Heart --; E. Pharmacologic Basis for the Clinical Use of Ergot Alkaloids --; F. References --; VI Effects on the Central Nervous System --; A. Introduction --; B. Early Evidence of Central Effects --; C. Whole-Animal Studies --; D. Synaptic Transmission: Catecholaminergic Mechanisms --; E. Synaptic Transmission: Serotoninergic Mechanisms --; F. Brain Metabolism --; G. References --; VII Clinical Pharmacology of Ergot Alkaloids in Senile Cerebral Insufficiency --; A. Introduction --; B. Terminology, Etiology, and Pathology of the Aging Process of the Brain --; C. Research Techniques Used in Clinical Pharmacologic Studies of Ergot Alkaloids in Senile Cerebral Insufficiency --; D. Results of Clinical Pharmacology Studies With Ergot Alkaloids --; E. Summary --; F. References --; VIII Some Compounds With Hallucinogenic Activity --; A. Introduction --; B. Discovery of LSD --; C. Effects of LSD in Man --; D. Clinical Applications of LSD --; E. LSD Analogues Tested in Man --; F. Cross-Tolerance --; G. References --; IX Influence on the Endocrine System --; A. Animal Data --; B. Human Data --; C. References --; X Metabolic Effects --; A. Introduction --; B. In Vitro Systems --; C. Intact Animals and Men --; D. Various Actions of Ergot Alkaloids --; E. References --; XI Biopharmaceutical Aspects. Analytical Methods, Pharmacokinetics, Metabolism and Bioavailability --; A. Introduction --; B. Assay of Ergot Alkaloids --; C. Pharmacokinetics --; D. Metabolism --; E. References --; XII Toxicologic Considerations --; A. Introduction --; B. Systemic Toxicity --; C. Effects on Reproductive Processes --; D. Potential Genetic Effects --; E. Interactions Leading to Enhanced Toxicity --; F. Summary --; G. References --; Authors Index.

With contribution by numerous experts

Pharmacy.

edited by B. Berde, H.O. Schild.

B Berde

H O Schild

[Book]

Y