عنوان

Drug-induced hepatotoxicity

3642610137

9783642610134

b571678

Drug-induced hepatotoxicity

[Book]

contributors, S. Anuras [and others] ; editors, R.G. Cameron, G. Feuer, and F.A. de la Iglesia.

Berlin ; New York

Springer

©1996.

(xxxi, 681 pages) : illustrations

Handbook of experimental pharmacology, v. 121.

1: Orientation in Liver Toxicity by Drugs --; 2: Clinical Studies and Role of Necrosis in Hepatotoxicity (With 7 Figures) --; 3: Subcellular Biochemical and Pathological Correlates in Experimental Models of Hepatotoxicity (With 5 Figures) --; 4: Molecular Biology of Hepatic Drag Reactions (With 6 Figures) --; 5: In Vitro Models of Liver Toxicity (With 4 Figures) --; 6: Cytochromes P450 and Liver Injury (With 4 Figures) --; 7: Mechanisms of Drug-Induced Cholestasis --; 8: Fatty Liver and Drugs (With 1 Figure) --; 9: Choline Deficiency: An Important Model for the Study of Hepatotoxicity (With 2 Figures) --; 10: Immune Mechanisms and Liver Toxicity (With 3 Figures) --; 11: Hepatic Encephalopathy --; 12: Liver Drug Reactions and Pregnancy --; 13: Pediatric Hepatic Drug Reactions --; 14: Reye's Syndrome --; 15: Drug Hepatotoxicity in the Elderly (With 7 Figures) --; 16: Effect of Liver Disease on Drug Metabolism and Pharmacokinetics (With 6 Figures) --; 17: Liver Reactions to Tacrine (With 2 Figures) --; 18: Mechanisms of Hypertransaminemia (With 7 Figures) --; 19: Diagnostic Tools and Clinical Pathology --; 20: Antimicrobial Drugs (With 7 Figures) --; 21: Hepatotoxicity of Cardiovascular Drugs (With 9 Figures) --; 22: Analgesie Hepatopathy --; 23: Steroids and Other Hormones (With 7 Figures) --; 24: Hepatotoxicity of Immunomodulating Agents --; 25: Alcohol-Induced Liver Injury --; 26: Antiepileptic Drugs (With 10 Figures).

This book discusses drug-induced hepatotoxicity in its entirety from details of molecular mechanisms to clinical case presentations. Special features of drug-induced hepatotoxicity during pregnancy, in pediatric practice, and in the elderly are described. It is complemented by a complete index of all drugs and a comprehensive table of contents allows ready access to all of the knowledge concerning each drug and each class of drugs. Special features include chapters on Reye's syndrome, in vitro models of liver toxicity, hepatic encephalopathy, and alcohol-induced liver injury. The reader will benefit from the scholarly approach to the subject, from the detailed discussions of mechanims and from the attention to details of hepatic responses to each drug.

Chemical and Drug Induced Liver Injury.

Drugs -- Toxicology.

Hepatotoxicology.

contributors, S. Anuras [and others] ; editors, R.G. Cameron, G. Feuer, and F.A. de la Iglesia.

Felix A De la Iglesia

George Feuer

R G Cameron

S Anuras

[Book]

Y