1. Brief Introduction to Cushing's Syndrome and Disease --;References --;2. Physiology of Regulation of ACTH Secretion --;A. Chemistry of ACTH --;B. Histology --;C. Physiology of ACTH Secretion --;References --;3. ACTH Action --;A. Structure-Function Relationships --;B. Effect on Adrenal Size, Morphology, and Growth --;C. Mechanism of ACTH Action of Steroidogenesis --;D. Effect of ACTH on Aldosterone Secretion --;E. Dynamics of ACTH Secretion --;F. Extra-adrenal Metabolic Actions of ACTH --;G. Behavioral Effects of ACTH --;References --;4. Actions of Adrenocortical Hormones --;A. Pathways of Corticosteroid Biosynthesis --;B. Mechanism of Glucocorticoid Action --;References --;5. The Nature of ACTH-Related Peptides in Cushing's Disease and Syndrome --;References --;6. Clinical Manifestations of Cushing's Disease and Cushing's Syndrome --;A. Cushing's Disease --;B. Adrenal Tumors --;C. 'Primary' Pituitary Tumor --;D. Ectopic ACTH Production --;E. Differential Diagnosis of Cushing's Disease and Syndrome --;References --;7. Laboratory Diagnosis of Cushing's Disease and Syndrome --;A. Measurement of Basal Corticosteroid Production --;B. Plasma ACTH Concentrations --;C. ACTH-Related Peptides: Lipotropin, Endorphin, and MSH --;D. Tests Involving Pituitary-Adrenal Stimulation and Suppression --;E. Response to Hypothalamic-Releasing Hormones --;F. Usefulness of Hormonal Tests in Differential Diagnosis --;G. Venous Catheterization for Ectopic ACTH-Producing Tumor Localization --;H. Pituitary X-Ray Localization --;J. Adrenal Localization --;References --;8. Treatment of Cushing's Disease and Syndrome --;A. Adrenal Adenoma --;B. Adrenocortical Carcinoma --;C. Ectopic ACTH-Producing Tumors --;D. Cushing's Disease --;References.
It took approximately 90 years to isolate this elusive vital factor - cortisone - from beef adrenal cortices, independently by both Reichstein and his co-workers in Basle and Kendall and his group in the United States and another 10-15 years before it became more generally available for experimental and clinical use.