عنوان

Local Anesthetics

3642711103

9783642711107

b558419

Local Anesthetics

[Book]

edited by Gary R. Strichartz.

Berlin, Heidelberg

Springer Berlin Heidelberg

1987

(52 illustrations)

Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie, 81.

1 Some Aspects of the History of Local Anesthesia --;A. Introduction --;B. Freud, Koller and the Early History of Cocaine --;C. Structure and Synthesis of Local Anesthetics --;D. Epinephrine and Local Anesthesia --;E. Toxicity of Local Anesthetics --;F. The Nervous Impulse and the Action of Local Anesthetics --;G. Pharmacokinetics of Local Anesthetics --;H. Summary and Conclusions --;References --;2 The Action of Local Anesthetics on Ion Channels of Excitable Tissues --;A. Introduction --;B. Physiological Basis of Generation of the Action Potential --;C. The Action of Local Anesthetics on Sodium Channels --;D. Current Questions in Local Anesthetic Action --;E. New Kinds of Local Anesthetic Agents --;F. Effects of Local Anesthetics on Potassium Channels --;G. Conclusion --;References --;3 Structural Elements which Determine Local Anesthetic Activity --;A. Introduction --;B. Structure and Physico-Chemical Properties of Local Anesthetics --;C. Resolution of Structural Contributions to Potency --;D. Comparisons of Nerve Blocking Actions with Antiarrhythmic Actions of Local Anesthetics --;E. Models for Local Anesthetic Receptors --;References --;4 Mechanisms of Differential Nerve Block --;A. Introduction --;B. Historical Discussion --;C. Confirmations, Extensions, Clarifications, and Contradictions --;D. Summary and Conclusion --;References --;5 Pharmacokinetics of Local Anesthetics --;A. Introduction --;B. Factors Affecting the Interpretation of Local Anesthetic Blood Concentrations --;C. Metabolism --;D. Pharmacokinetics in Man --;E. Factors Affecting Pharmacokinetics of Local Anesthetics --;F. Pharmacokinetics in Experimental Animals --;References --;6 Toxicity and Systemic Effects of Local Anesthetic Agents --;A. Effects on the Central Nervous System --;B. Effects on the Cardiovascular System --;C. Effects on the Neuromuscular Junction --;D. Miscellaneous Effects --;E. Other Toxicological Effects --;F. Treatment of Systemic Toxicity --;G. Local Tissue Toxicity --;H. Summary --;References --;7 The Role of Local Anesthetic Effects in the Actions of Antiarrhythmic Drugs --;A. Introduction --;B. Electrophysiology of Cardiac Fibers --;C. The Effects of Local Anesthetics on Cardiac Fibers --;D. Antiarrhythmic Effects of Local Anesthetic Agents --;E. Conclusion --;References --;8 Central Effects of Local Anesthetic Agents --;A. Introduction --;B. Routes of Entry of Local Anesthetic Agents into the CNS --;C. Behavioral Pharmacology of Local Anesthetic Agents --;D. Effects of Local Anesthetics on Electrical Activity of the Brain --;E. Anticonvulsant Properties of Local Anesthetics --;F. Temporal and Spatial Effects of Local Anesthetics at Regional CNS Sites --;G. The Mechanisms Underlying Local Anesthetic-Induced Seizures --;H. Central Nervous System Metabolic Effects of Local Anesthetics --;I. Summary --;References.

Local anesthetics are among the most widely used drugs. Relief of acute pain, accompanying dental manipulations, for example, and of chronic pain are also accomplished with traditional local anesthetics.

Medicine.

Pharmacy.

Toxicology.

edited by Gary R. Strichartz.

Gary R Strichartz

[Book]

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