Contributors. Preface; N. Chattopadhyay, E.M. Brown. 1. An overview of extracellular calcium homeostasis and the roles of the CaR in the parathyroid and C-cells; A. Mithal, E.M. Brown. 2. Structure-function relationship of the extracellular calcium-sensing receptor; Mei Bai. 3. Calcium receptor-mediated signaling; K.D. Rodland. 4. Extracellular Ca2+- sensing receptor and kidney function; D. Riccardi, S.C. Hebert. 5. Calcium- sensing receptor in bone; T. Yamaguchi. 6. Functions in the calcium-sensing receptor in the gastrointestinal system; R.J. MacLeod. 7. The calcium-sensing receptor (CaR) and human disease; C.H. Kos, M.R. Pollak. 8. Compounds acting on the parathyroid calcium receptor as novel therapies for hyperparathyroidism or osteoporosis; E.F. Nemeth, J. Fox. 9. Alternative agonists and modulators: evidence that the calcium sensing receptor is a multi-modal sensor; S.J. Quinn, A.D. Conigrave. 10. Expression and functions of calcium-sensing receptor in the central nervous system; Chianping Ye, et al. 11. The role of the calcium receptor in calcium regulated keratinocyte differentiation; Chia-Ling Tu, et al. Calcium sensing receptor and neoplastic transformation; E. Kallay, et al.