I. Statistical Analysis.- 1. Epidemiology and Statistical Analysis of Gliomas.- 2. Statistical Considerations of Therapeutic Results in Glioblastoma.- II. Basic Studies.- 3. Combined Effects of Radiation, ACNU, and 5-FU on Gliomas: An Experimental Combination Therapy.- 4. The Pharmacokinetics of ACNU in Patients with Malignant Brain Tumor.- 5. The Effects of Induced Hypertension on the Uptake of ACNU in Experimental Brain Tumor.- 6. A Study of Intratumoral Oxygen Pressure in Brain Tumors.- III. Clinical Studies.- 7. An Outline of RAFP Therapy.- 8. Results of RAFP Therapy on CT Scan.- 9. Clinical Analysis of Glioma: Anaplastic Astrocytoma and Glioblastoma.- 10. Clinical Analysis of Glioma: Low-Grade Astrocytoma.- 11. Clinical Analysis of Glioma: Oligodendroglioma.- 12. Clinical Analysis of Glioma: Ependymoma.- 13. Clinical Analysis of Glioma: Medulloblastoma.- 14. Side Effects of RAFP Therapy.- 15. Clinical Study Using MRI in Patients Treated with RAFP Therapy.