Cancer Gene Therapy: Historical Perspective Malcolm K. Brenner The Genetic Basis of Cancer Akseli Hemminki and Kari Hemminki Tumor Suppressor Gene Replacement for Cancer Jack A. Roth and Susan F. Grammer Antisense Technology Ruiwen Zhang and Hui Wang Cancer Therapeutic Applications of Ribozymes and RNAi Lisa Scherer and John J. Rossi. Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy: A Better Class of Killer Andrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, and Richard Vile Suicide Gene Therapy Caroline J. Springer and Ion Niculescu-Duvaz Molecular Chemotherapy Approaches Daniel H. Palmer and David J. Kerr Genetic Immunotherapy Approaches Denise R. Shaw and Albert F. LoBuglio Immunotherapy of Cancer By Dendritic Cell-Targeted Gene Transfer Tanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper. Dendritic Cells Weiping Zou, Shuang Wei, and Tyler J. Curiel Polynucleotide Immunization for Cancer Therapy Theresa V. Strong Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors: The G207 Paradigm Tomoki Todo and Samuel D. Rabkin Development of Oncolytic Adenoviruses: From the Lab Bench to the Bedside John A. Howe, Robert Ralston, and Murali Ramachandra Conditionally Replicating Adenoviruses for Cancer Treatment Ramon Alemany Reovirus as an Oncolytic Agent Megan K. Patrick, Kara L. Norman, and Patrick W. K. Lee Antiangiogenic Gene Therapy of Cancer Steve Gyorffy, Jack Gauldie, A. Keith Stewart, and Xiao-Yan Wen Proapoptotic Strategy in Cancer Gene Therapy David H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, and James S. Norris Antimetastasis Duen-Hwa Yan, Kung-Ming Rau, and Mien-Chie Hung Antimetastatic Gene Therapy: Prostate Cancer Theory to Therapy Thomas A. Gardner, Juan Antonio Jimenez, Leland W. K. Chung, and Chinghai Kao Drug Resistance Gene Transfer as an Antitumor Strategy Colin L. Sweeney and R. Scott McIvor Chemosensitization Per Eystein Lonning Radiosensitization by Gene Therapy Steven J. Chmura, Michael Garofalo, and Ralph R. Weichselbaum Nonviral Vector Systems for Cancer Gene Therapy Greg F. Walker and Ernst Wagner Viral Vectors for Cancer Gene Therapy Joanne T. Douglas and David T. Curiel Bacterial Systems for Tumor-Specific Gene Therapy J. Martin Brown, Shie-Chau Liu, Jan Theys, and Philippe Lambin Molecular Imaging of Cancer Gene Therapy Harvey R. Herschman Cancer-Related Gene Therapy Clinical Trials Robert J. Korst and Ronald G. Crystal Regulatory Aspects in the Development of Gene Therapies Rosemarie Aurigemma, Joseph E. Tomaszewski, Sheryl Ruppel, Stephen Creekmore, and Edward A. Sausville Index