One Classification and Histology.- 1 Vasculitis - then and now.- 2 Classification and histopathologic specificity of systemic vasculitis.- Two Disease Mechanisms and Investigations.- 3 Vasculitis: mechanisms of injury.- 4 Antineutrophil cytoplasmic antibodies (ANCA): current perspectives.- 5 Antiendothelial cell antibodies, antiphospholipid antibodies and vascular disease.- 6 Adhesion molecules in disease: vascular cell adhesion molecule-1 as a target for therapy.- 7 MRI and CT in vasculitis.- 8 Angiography in vasculitis: its role in diagnosis and in the management of complications.- Three Pri.