عنوان

Monoclonal antibodies in cancer

1461251761

146129598X

9781461251767

9781461295983

b553322

Monoclonal antibodies in cancer

[Book]

edited by Stewart Sell and Ralph A. Reisfeld.

Clifton, N.J.

Humana Press

©1985.

(xviii, 428 pages) : illustrations

Contemporary biomedicine.

1 Monoclonal Antibody Defined Antigens on Animal Tumors --;1. Introduction --;2. Antigen Expression on Chemically Induced Tumors --;2.1. Murine Tumors --;2.2. Rat Tumors --;2.3. Guinea Pig Tumors --;3. Use of Monoclonal Antibodies in Tumor Localization and Therapy --;3.1. In Vivo Localization of Monoclonal Antibodies in Experimental Tumors --;3.2. Serotherapy Using Antitumor Monoclonal Antibodies --;3.3. Therapy Using Antitumor Monoclonal Antibodies Conjugated to Cytotoxic Agents --;4. Conclusion --;References --;2 Monoclonal Carcinoembryonic Antigen Antibodies --;1. Introduction --;2. The Development of Monoclonal CEA Immunoassays --;2.1. General Concepts of Monoclonal Antibody Methodology --;2.2. Experimental and Clinical Experience with Monoclonal CEA Antibodies --;3. Monoclonal Antibodies in the Immunohistological Evaluation of CEA --;4. Monoclonal Anti-CEA Antibodies in Tumor Imaging --;5. Immunotherapy with Monoclonal CEA Antibodies --;6. Summary --;References --;3 Monoclonal Antibodies to Alphafetoprotein and Regulation of AFP Gene Expression --;1. Introduction --;2. Monoclonal Antibodies to AFP --;2.1. ELISA Using Monoclonal Antibodies --;2.2. Immune Localization Using Anti-AFP --;2.3. Radioimmunescintigraphy --;2.4. Immunotherapy --;3. Control of AFP Gene Expression --;3.1. AFP and Albumin Gene Expression During Development --;3.2. AFP and Albumin Gene Structure --;3.3. AFP and Albumin Gene Expression and Methylation --;4. Summary --;References --;4 Human Chorionic Gonadotropin Detection with Monoclonal Antibodies --;1. Introduction: hCG Chemistry and Immunochemistry with Antisera --;2. Description of Monoclonal Antibodies to hCG --;2.1. Affinity, Isotype, Subclass, and Cross-Reactivity of Antibodies --;2.2. Topological Mapping of Monoclonal Antibodies: Relative Orientation of Epitopes --;2.3. Biological Effects of Monoclonal Antibodies Against hCG --;2.4. Special Properties of Monoclonal Antibodies to hCG: Synergistic Effects --;3. Immunoassays with Monoclonal Antibodies to hCG --;3.1. Description of Commercial Immunoassays for hCG Employing Monoclonal Antibodies --;3.2. Research Immunoassays for hCG --;4. In Vivo Immunodetection of Tumors --;5. Immunocytochemistry with Monoclonal Antibodies to hCG --;6. Summary --;References --;5 Products of the Major Histocompatibility Complex on Tumor Cells --;1. Introduction --;2. Variable Expression of MHC Antigens by Tumor Cells --;2.1. Inducible MHC Antigens on Murine Tumors Cells --;2.2. Inducible MHC Antigens on Human Tumors --;2.3. Implications for Human Tumor Immunology --;3. Abnormal Expression of MHC Antigens by Tumor Cells --;3.1. Abnormal Expression of MHC Antigens on Murine Tumor Cells --;3.2. Abnormal Expression of MHC Antigens on Human Tumor Cells --;4. Conclusions --;References --;6 Monoclonal Antibodies: Probes for the Study of Malignant T Cells --;1. Introduction --;2. Monoclonal Antibodies as Probes for the Study of Malignant T Cells --;3. Normal T-Cell Maturation as Defined by Monoclonal Antibodies --;4. Phenotypic Analysis of Malignant T Cells in Defined Clinical Syndromes --;4.1. T-Cell Acute Lymphoblastic Leukemia --;4.2. T-Cell Lymphoblastic Lymphoma --;4.3. T-Cell Prolymphocytic Leukemia --;4.4. Cutaneous T-Cell Lymphoma --;4.5. T-Cell Chronic Lymphocytic Leukemia --;4.6. IgG Fc Receptor Beraing (TG) Lymphoproliferative Disease --;4.7. Hairy Cell Leukemia --;4.8. HTLV-Associated Japanese, Caribbean, and American Adult T-Cell Leukemia/Lymphoma (ATL) --;4.9. Diffuse Lymphomas --;4.10. T-Cell "Premalignant" Proliferative Disease --;4.11. Thymoma --;5. Summary and Conclusions --;References --;7 Antigenic Markers on Normal and Malignant B Cells --;1. Introduction --;2. Antigenic Markers on Normal B Cells --;3. Antigenic Markers on Malignant B Cells --;Bibliography for Further Reading --;8 Nonlymphoblastic Leukemia-Associated Antigens Identified by Monoclonal Antibodies --;1. Introduction --;2. Myeloid-Associated Antigens Expressed by Normal Hematopoietic Cells and Cell Lines --;2.1. Monoclonal Antibodies to Antigens Expressed Primarily on Granulocytes --;2.2. Monoclonal Antibodies to Antigens Primarily Expressed by Monocytes --;2.3. Monoclonal Antibodies to Antigens Associated with Granulocytes and Monocytes --;2.4. Monoclonal Antibodies to Antigens Primarily Expressed on Immature Granulocytes and Monocytes --;2.5. Antibodies Against Erythroid and Megakaryocytic Lineage-Associated Antigens --;2.6. Myeloid-Associated Antigens Expressed by Hematopoietic Progenitors --;2.7. Expression of Myeloid-Associated Antigens During Ontogeny and Phylogeny --;2.8. Myeloid-Associated Antigens on Human Myeloid Cell Lines --;3. Expression of Myeloid-Associated Antigens by Myeloid Leukemias --;3.1. Diagnosis of Acute Nonlymphoblastic Leukemia Using Monoclonal Antibodies: Discrimination from ALL --;3.2. Subsets of Acute Nonlymphoblastic Leukemia Defined by Monoclonal Antibodies --;3.3. Prognostic Implications of Cell Surface Phenotype --;4. Monoclonal Antibodies as Probes of Leukemic Stem Cell Phenotype and Differentiation --;5. Therapy of Myeloid Leukemias Using Antibodies to Leukemia-Associated Antigens --;6. Conclusions --;References --;9 Monoclonal Antibodies as Probes for the Molecular Structure and Biological Function of Melanoma-Associated Antigens --;1. Introduction --;2. Immunological Characterization of Monoclonal Antibodies --;3. Immunochemical and Molecular Profiles of Human Melanoma-Associated Antigens --;3.1. Glycoproteins --;3.2. Glycolipids --;4. Biosynthesis and Structure of Melanoma-Associated Antigens --;5. Function of Melanoma Antigens Defined by Monoclonal Antibodies --;5.1. In Vitro Studies --;5.2. In Vivo Studies --;6. Conclusions --;References --;10 Lung Cancer Markers as Detected by Monoclonal Antibodies --;1. Introduction --;2. Methods --;3. Characterization Studies --;4. Monoclonal Antibodies to Small-Cell Lung Cancer --;4.1. Analysis of Antigen Expression in Small-Cell Lung Cancer --;5. Monoclonal Antibodies to Nonsmall-Cell Lung Cancer --;6. Monoclonal Antibodies to Defined Proteins of Lung Cancer --;7. Imaging Lung Cancer with Monoclonal Antibodies --;8. Monoclonal Antibodies with Therapeutic Applications --;8.1. In Small-Cell Lung Cancer Variants --;8.2. In Small-Cell Lung Cancer --;9. Summary --;References --;11 Human Breast Cancer Markers Defined by Monoclonal Antibodies --;1. Introduction --;2. Generation of Monoclonal Antibodies --;3. Mammary Carcinoma Tissue as Immunogen for the Preparation of Monoclonal Anbibodies to Carcinoembryonic Antigen (CEA) --;4. Identification and Purification of Mammary Tumor-Associated Antigens --;5. Antigenic Modulation and Evolution Within Human Mammary Carcinoma Cell Populations --;6. Differential Reactivity of a Monoclonal Antibody (DF3) with Human Malignant Vs Benign Breast Tumors --;7. Radiolocalization of Human Mammary Tumor Transplants in Athymic Mice by a Monoclonal Antibody --;8. The Use of Recombinant Interferon to Enhance Detection of Human Carcinoma Antigens by Monoclonal Antibodies --;References --;12 Antigens of Normal and Malignant Human Exocrine Pancreatic Cells --;1. Introduction --;2. Human Pancreatic Cell Antigens Defined by Polyclonal Antibodies --;2.1. Polyclonal Antibodies Elicited to Normal Adult Pancreas or to Pancreatic Secretions --;2.2. Polyclonal Antibodies Elicited to Fetal Pancreas --;2.3. Polyclonal Antibodies Elicited to Pancreatic Tumors --;3. Pancreatic Antigens Defined by Monoclonal Antibodies --;3.1. Monoclonal Antibodies Elicited to Normal Pancreatic Cell Antigens --;3.2. Monoclonal Antibodies Reactive with Pancreatic Tumor-Associated Antigens --;4. General Discussion --;References --;13 Monoclonal Antibodies to Human Prostate Cancer-Related Antigens --;1. Introduction --;2. Cell Surface Antigens of Established Prostate Tumor Lines --;3. Prostate Membrane-Associated Antigens --;4. Prostate Antigen --;5. Prostatic Acid Phosphatase --;6.

Monoclonal antibody technology from its earliest moments has offered revolutionary expectations for the diagnosis and treatment of cancer.

Cancer -- Diagnosis.

Monoclonal antibodies.

Tumor antigens -- Analysis.

edited by Stewart Sell and Ralph A. Reisfeld.

Ralph A Reisfeld

Stewart Sell

[Book]

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