عنوان

Principles of molecular medicine

1475762720

1592597262

9781475762723

9781592597260

b552710

Principles of molecular medicine

[Book]

edited by J. Larry Jameson ; foreword by Francis S. Collins.

Totowa, N.J.

Humana Press

©1998.

(xix, 1123 pages) : illustrations

I. Introduction to Molecular Medicine --;1 Organization of the Human Genome, Chromosomes, and Genes --;2 Recombinant DNA and Genetic Techniques --;3 Transcriptional Control of Gene Expression --;4 Transmission of Human Genetic Disease --;5 The Human Genome Project --;6 The Cell Cycle --;7 Oncogenes and Tumor Suppressor Genes --;8 Molecular Diagnostic Testing --;9 Genetic Counseling --;10 Transgenic Mice as Models of Disease --;II. Cardiology --;11 Molecular Cardiology: An Overview --;12 Congenital Heart Disease --;13 Inherited Cardiomyopathies --;14 Coronary Atherosclerosis --;15 Endothelium-Derived Nitric Oxide and Control of Vascular Tone --;16 Hypertension --;17 Cardiac Arrhythmias --;18 Cardiovascular Gene Therapy --;III. Hematology --;19 Hematopoiesis: Growth Factorsand Mechanisms of Regulation --;20 Disorders of Hemoglobin Structure and Synthesis --;21 Disorders of the Red Cell Membrane --;22 Red Cell Enzymopathies --;23 Coagulation Disorders --;24 Thrombotic Disorders --;25 Paroxysmal Nocturnal Hemoglobinuria --;26 Leukemias --;27. Lymphomas --;IV. Immunology --;28 Regulation of Humoral Immunity --;29 Molecular Regulation of Cellular Immunity --;30 Cytokines --;31 The HLA Complex --;32 Inherited Immune Deficiency --;33 Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (AIDS) --;34 Autoimmune Diseases --;35 Allergic Diseases: Asthma as a Model --;V. Pulmonology --;36 Asthma --;37 Cystic Fibrosis --;38 Pulmonary Emphysema --;39 Surfactant Deficiency --;40 Lung Cancer: The Role of Tumor Suppressor Genes --;VI. Gastroenterology --;41 Hepatology --;42 Inherited Liver Disease --;43 Viral Hepatitis and Liver Disease --;44 Pancreatic Exocrine Dysfunction --;45 Small- and Large-Bowel Dysfunction --;VII. Endocrinology --;46 Mechanisms of Hormone Action --;47 Diabetes Mellitus --;48 Pituitary Function and Neoplasia --;49 Growth Hormone Deficiency Disorders --;50 Thyroid Disorders --;51 Disorders of the Parathyroid Gland --;52 Congenital Adrenal Hyperplasia --;53 Adrenal Diseases --;54 Multiple Endocrine Neoplasia Type 2 --;5 5 Molecular Mechanisms of Hypoglycemia Associated with Increased Insulin Production --;56 Regulation of Reproduction --;57 Disorders of Sex Determination and Differentiation --;58 Sex Chromosome Disorders --;59 Disorders of Pubertal Development --;60 Defects of Androgen Action --;61 Testicular Diseases --;62 Ovarian Diseases --;63 Breast Cancer --;VIII. Nephrology --;64 Renal Development --;65 Mechanisms of Leukocyte Extravasation --;66 Ischemic Acute Renal Failure --;67 Potassium Secretory Channels in the Kidney --;68 Alport Syndrome --;69 Nephrogenic Diabetes Insipidus --;70 Polycystic Kidney Disease --;71 Renal Neoplasms: Wilms' Tumor and Renal-Cell Carcinoma --;IX. Dermatology --;72 Introduction to Selected Epidermal Gene Mutations --;73 Epidermolysis Bullosa Simplex --;74 Epidermolytic Hyperkeratosis --;75 Mosaicism and Epidermal Nevi --;76 Darier's Disease and Hailey-Hailey Disease --;77 Junctional Forms of Epidermolysis Bullosa --;78 The Dystrophic Forms of Epidermolysis Bullosa --;79 Oculocutaneous Albinism --;80 Basal Cell Nevus Syndrome --;81 Xeroderma Pigmentosum and Related Disorders --;82 The Skin as a Vehicle for Gene Therapy --;83 Acquired Diseases of Cutaneous Tissues: Introduction --;84 Basal- and Squamous-Cell Carcinomas --;85 Melanoma Genetics --;86 Psoriasis --;87 Atopic Dermatitis and Atopy --;88 Pemphigus Foliaceus and Pemphigus Vulgaris --;89 Bullous Pemphigoid, Cicatricial Pemphigoid, and Pemphigoid Gestationis --;90 Cutaneous Lupus Erythematosus --;91 Scleroderma (Systemic Sclerosis) and Morphea --;X. Musculoskeletal --;92 Muscle Development and Differentiation --;93 Skeletal Muscle Structure and Function --;94 Muscular Dystrophies --;95 Rhabdomyosarcomas --;XI. Neurology --;96 Molecular Neurobiology --;97 Huntington's Disease --;98 Molecular Genetics of Alzheimer's Disease --;99 Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases --;100 Spinocerebellar Ataxia and Other Disorders of Trinucleotide Repeats --;101 Charcot-Marie-Tooth Disease and Related Peripheral Neuropathies --;102 Molecular and Genetic Basis of Prion Diseases --;103 Genetic Basis of Mitochondrial Disease --;104 Malignant Hyperthermia and Central Core Disease --;105 Retinoblastoma --;106 Neurofibromatosis: Type 1 and Type 2 --;107 Brain Tumors --;XII. Psychiatry --;108 Molecular Mechanisms and Regulating Behavior --;109 Schizophrenia --;110 Affective Disorders --;111 Alcoholism --;XIII. Genetic Basis of Congenital Malformations --;112 Waardenburg Syndrome --;113 Greig Cephalopolysyndactyly Syndrome and Limb Disorders --;114 Fibroblast Growth Factor Receptor-Related Skeletal Disorders: Craniosynostosis and Dwarfism Syndromes --;115 Aarskog-Scott Syndrome --;116 Beckwith-Wiedemann Syndrome --;117 Prader-Willi and Angelman Syndromes --;118 Fragile X Syndrome --;119 Down Syndrome --;120 The 22q11 Deletion: DiGeorge and Velocardiofacial Syndrome --;121 Orofacial Clefting --;122 Molecular Genetics of Hearing Disorders.

Principles of Molecular Medicine is the first major textbook to integrate the basic principles of internal medicine with the rapidly growing body of revolutionary findings from cell and molecular biology, including the human genome project. In its pages, J. Larry Jameson and his authoritative contributors, many of them world-renowned clinicians and researchers, expand the envelope of clinical understanding to encompass a wide array of specialties-including neurology, cardiology, hematology, nephrology, genetics, endocrinology, oncology, dermatology, and psychiatry-revealing the underlying molecular mechanisms of disease, as well as novel routes to the unprecedented treatments now emerging from these new molecular approaches. Practicing physicians will find informative updates in both their own specialties and in disciplines they may not have been able to follow closely. Within the framework of clinical internal medicine, they will gain critical knowledge ofthe many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more. Principles of Molecular Medicine offers a brilliant and original synthesis of today's rapidly advancing insights-fostered by genetics and molecular biology-into the nature and treatment of disease, codifying the major paradigm shift now underway in the teaching and practice of medicine. Certain to become a vital complement to traditional medical textbooks, Principles of Molecular Medicine provides practicing physicians, residents, medical students, and researchers alike with an authoritative and practical account of today's internal medicine, as well as insights into the nature and direction of future developments.

Molecular medicine

Medical genetics.

Molecular biology.

Pathology, Molecular.

edited by J. Larry Jameson ; foreword by Francis S. Collins.

J Larry Jameson

[Book]

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