The impact of genomics on therapeutic drug development.- Regulation of mammalian gene expression.- New trends in antimicrobial development.- Trends in antifungal research.- Vaccines and infectious disease.- Manipulation of polyketide biosynthesis for new drug discovery.- Physiological functions of protein kinase inhibitors.- Molecular approaches to receptors as targets for drug discovery.- Peroxisome proliferator activated receptor agonists.- Tomorrow's anticancer agents: inhibitors of Ras farnesylation.- The future of obesity treatment.- Antithrombotic therapy in acute coronary syndromes.- Strategies to delay the onset of Alzheimer's disease.- Delivery systems and adjuvants for vaccination against HIV.
New technological innovations create an almost unlimited array of domains in which drugs can act with increasing precision and less side-effects. Novel tools give concise insights into gene, membrane and protein interactions leading to the development of specific 'tailor-made' drugs. New Approaches to Drug Development reviews latest discoveries in drug research and highlights some of the many therapeutic possibilities whose growing applications can only be estimated in part. This profound and extensive documentation of novel findings and outlooks in drug development and delivery systems contains contributions of leading scientists in the fields of genetics and molecular biology, pharmacology, genetic engineering and psychiatry. Many of their evaluations are not just restricted to specific diseases, but encompass infections, coronary syndromes and syndromes associated with dysfunctions on the genetical, cellular, physiological and metabolic level in general ...