عنوان

Toxicology in Transition :

3642794513

9783642794513

b549993

Toxicology in Transition :

[Book]

Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21-24, 1994

edited by Gisela H. Degen, Jürg P. Seiler, Philip Bentley.

Berlin, Heidelberg

Springer Berlin Heidelberg

1995

(ix, 569 pages 104 illustrations).

Archives of toxicology., Supplement ;, 17.

Genetically Modified Cells and Animals in Toxicological Research.- Concepts, potentials, methods for constructing transgenic cells and animals - Introduction.- Use of recombinant cells in metabolic and mechanistic studies (analysis of pathways).- Applications for transgenic animals in toxicology.- The Benchmark Dose Concept.- Principles, benefits and limitations of the NOEL approach.- Comparison of benchmark doses (BMD) with no-observed-adverse-effect-levels (NOAEL) and low-observed-adverse-effect-levels (LOAEL) for subchronic studies.- Bfoindicators in Ecotoxicology.- Bioindicators in ecotoxicology: an overview.- Use of cytochrome P450 1A in fish as a biomarker of aquatic pollution.- Receptor-mediated toxicity.- Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression.- Inhibitors of the sodium pump: toxins, then drugs, and now hormones.- Rodent responses to peroxisome proliferators - a receptor-mediated phenomenon ?.- Role of second messengers in mineral particle-induced production of reactive oxygens species by phagocytes.- Estrogenic effects of some xenobiotics.- In Vitro tests in regulatory toxicology.- In Vitro methods in regulatory toxicology: the crucial significance of validation.- Scientific, ethical and legal aspects of the acceptance of in vitro methods in regulatory toxicology.- The validation and use of in vitro teratogenicity tests.- In Vitro methods in regulatory toxicology.- In Vitro tests in regulatory toxicology: symposium chairman's summing-up.- Ex Vivo and in Vitro Models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism.- Rabbit renal proximal tubule suspensions as a model for nephrotoxicity evaluation of native or in situ metabolized B-lactam antibiotics.- Neurobehavioral abnormalities induced by substance abuse.- Neurobehavioral abnormalities induced by prenatal exposure to substances of abuse - stating the problem.- Prenatal exposure to marihuana and tobacco during infancy, early and middle childhood: effects and an attempt at synthesis.- Delayed developmental neuro-and immunotoxicity of benzodiazepines.- Changes of EEG of freely-moving rats caused by three generation organophosphate treatment.- Developmental neurotoxicity of carbon monoxide.- Safety assessment of over the counter (OTC) products.- The safety assessment of over the counter (OTC) products.- OTC pharmaceuticals and genotoxicity testing: the paracetamol, anthraquinone, and griseofulvin cases.- Safety assessment of OTC products: doxylamine succinate.- Safety assessment of OTC products: a regulatory view.- Drug toxicity findings and no action taken.- Species specificity of organ toxicity.- Species specificity of organ toxicity.- Species specificity at the molecular level: the case of nitric oxide synthase.- Mechanisms underlying species-specificity in target organ specificity.- Species specificity of organ toxicity: behavioral differences.- Terrestrial ecotoxicity of chemical substances.- Development of OECD test guidelines and hazard assessment procedures for terrestrial effects.- Development of guidance for terrestrial effects assessment.- Application of quick and simple plant bioassays to assess the genotoxicity of environmental pollutants - Detection of potential health hazards of air, water and soil contaminants.- Comparison of susceptibility to chemicals (pesticides) of species used for human and environmental effect assessment.- Toxicological evaluation of pollutants in soil - concept of the AGU and assessment of tolerable concentrations for metals.- Immunodeflcient mouse systems.- The SCID (severe combined immnodeficiency) mouse - its biology and use in immunotoxicological research.- The SCID mouse as a tool to bridge the gap between animal and human responses.- The SCID mouse and its use in immunopharmacological and immunotoxicological investigations.- Stereochemical effects.- Chirality - from molecules to organisms.- Interactions between the in vitro metabolism of xenobiotics and fatty acids. The case of ibuprofen and other chiral profens.- Side effects and toxic reactions of chiral drugs: a clinical perspective.- Analysis of (S)-and (R)-propanolol in human plasma and urine by a specific immunoenzymtic assay versus HPLC.- Biological behavior of prestages of cancer cells.- Biological behavior of prestages of cancer cells: an introduction.- Preneoplastic lesions in kidney and carcinogenesis by non-genotoxic compounds.- Early cellular alterations in chemical liver carcinogenesis as assessed by immunohistochemical and molecular biological techniques.- Late Manuscripts.- The UK approach to the regulation and evaluation of novel foods produced by biotechnology.- Young Scientists Poster Award.- Molecular mimikry of CF3CO-lysine by lipoic acid I: the dehydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase as autoantigen in halothane hepatitis.- Molecular mimikry of CF3CO-lysine by lipoic acid II: lipoic acid bearing proteins as autoantigen in halothane hepatitis.

The volume contains the main papers presented at the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. This is reflected in symposia and workshops devoted to species differences in organ toxicity, receptor-mediated toxicity and stereochemical effects of xenobiotics.

Immunology.

Medicine.

Toxicology.

edited by Gisela H. Degen, Jürg P. Seiler, Philip Bentley.

Gisela H Degen

Jürg P Seiler

Philip Bentley

[Book]

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