عنوان

Restoration of brain function by tissue transplantation

0387558233

3540558233

9780387558233

9783540558231

b546361

Restoration of brain function by tissue transplantation

[Book]

O. Lindvall, ed. ; with contributions by O. Lindvall ... [et al.].

Berlin ; New York, N.Y.

Springer-Verlag, cop.

1993

x, 74 p. : ill. ; 28 cm.

Basic and clinical aspects of neuroscience, 5.

References.- Transplantation in Parkinson's Disease.- Experimental Studies in Animal Models of Parkinson's Disease.- 6-OHDA and MPTP Lesion Models.- Grafting of Embryonic Dopamine Neurons.- Human Embryonic Dopamine Neurons Grafted into the Rat Brain.- Grafting of Adrenal Medulla.- Clinical Studies in Patients with Parkinson's Disease.- Grafting of Adrenal Medulla.- Grafting of Embryonic Dopamine Neurons.- Research Strategies for the Development of a Transplantation Therapy in Parkinson's Disease.- Adrenal Medulla.- Embryonic Dopamine Neurons.- Other Approaches.- Conclusions.- References.- Transplantation in Huntington's Disease: Experimental Basis and Clinical Perspectives.- Experimental Model.- Implants of Fetal Striatal Primordia.- Intrinsic Organization of the Striatal Grafts.- Biochemical Markers of Striatal Graft Maturation and Function.- Amelioration of Lesion-Induced Behavioral Deficits.- Mechanisms of Action of the Intrastriatal Grafts.- Afferent Regulation of the Grafted Neurons.- Trophic Effects of Striatal Transplants.- Studies in Primates.- Clinical Perspectives.- References.- Neural Transplantation in Dementia.- Common Terminology in Research on Alzheimer's Disease.- Models of Cholinergic Deficiency.- Cholinergic Hypothesis.- Cholinergic Grafts in Rats and Monkeys with Lesions.- Cholinergic Grafts in Aging Animals.- Models of Trophic Factor Deficiency.- Role of NGF in Trophic Support.- Transplants as NGF Delivery Systems.- Critical Neuropathology of Alzheimer's Disease.- Cortical and Subcortical Cell Loss.- Amyloid, Plaques, and Tangles in Dementia.- Graft Models of the Cellular Pathology of Alzheimer's Disease.- Cellular Pathology in Aging Grafts.- Trisomy 16 Transplant Model.- Future Prospects for Better Functional Animal Models.- Clinical Prospects in Dementia.- References.- Transplantation in Experimental Epilepsy.- Noradrenergic Grafts in Experimental Epilepsy.- Hippocampal Kindling of NE-Depleted Forebrain.- Spontaneous and Picrotoxin-Induced Seizures in Animals with Subcortical Hippocampus Denervation.- Audiogenic Seizures in Genetically Epilepsy-Prone Rats.- Penicillin-Induced Seizures in Fetal Hippocampus Tissue Implanted in the Eye.- Other Grafts in Experimental Epilepsy.- Serotoninergic Neurons.- GABA-ergic Neurons.- Present Lines of Research and Clinical Perspectives.- Norepinephrine-Producing Grafts.- GABA-Producing Grafts.- Concluding Remarks.- References.- Genetically Modified Cells for Intracerebral Transplantation.- Genetically Modified Cells and the Neurotrophic Strategy.- Genetically Modified Cells for Neurotransmitter Replacement.- Discussion and Future Directions.- References.- Immunologic Aspects of Intracerebral CNS Tissue Transplantation.- General Aspects of Transplantation Immunology.- The Brain as a Transplantation Site.- Donor Tissue Properties.- Brain-Derived Antigen-Presenting Cells.- Inflammatory Responses.- Major Histocompatibility Complex Regulation in Grafted Tissue In Situ.- In Situ.- Regional Lymphatic Tissue.- Graft Vascularization and Blood-Brain Barrier Formation.- Lymphocyte Passage Across the Blood-Brain Barrier.- Locally Produced Immunosuppressive Factors.- Immunologic Experiences of Intracerebral Transplantation in Animals.- Prolonged Graft Survival in the Brain.- Immunologic Experience of Intracerebral Transplantation in Patients with Parkinson's Disease.- Conclusions.- References.

Malattie cerebrali -- Chirurgia.

Malattie cerebrali -- Terapia.

Trapianto di tessuto nervoso.

O. Lindvall, ed. ; with contributions by O. Lindvall ... [et al.].

et al

O Lindvall

[Book]

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