Overview of germinal center function and structure in normal and genetically engineered mice --;Relationship between the follicular dendritic cell reaction and germinal center development: normal, aged and retrovirus-infected mice --;T and B lymphocytes in germinal centers --;The mechanism of somatic hypermutation of immunoglobulin genes --;Germinal center derived lymphomas in humans and mice.-
This book meets the demand of a recent surge of interest in germinal centers, the foci of antigen-induced, rapidly proliferating B lymphocytes, representing sites in mammalian lymphoid tissue where memory B cells are generated.