Part II: Pharmacokinetics and Clinical Pharmacology
edited by Kurt Greeff.
Berlin, Heidelberg
Springer Berlin Heidelberg
1981
(xxi, 394 pages 64 illustrations)
Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie, 56 / 2.
Pharmacokinetics --;Distribution, Metabolism, and Elimination --;1 Pharmacokinetics of Digitoxin --;2 Pharmacokinetics of Digoxin and Derivatives --;3 Pharmacokinetics of Strophanthus Glycosides --;4 Pharmacokinetics of Squill Glycosides --;Pharmacokinetics --;Additional Pharmacokinetic Parameters of Cardiac Glycosides --;5 Plasma Protein Binding of Cardiac Glycosides --;6 Intestinal Absorption and Secretion of Cardiac Glycosides --;7 Cardiac Uptake and Binding of Cardiac Glycosides --;8 Bioavailability of Cardiac Glycosides --;9 Pharmaceutical Quality Control Standards for Cardiac Glycosides --;Clinical Pharmacology --;10 Effects of Cardiac Glycosides on the Failing and Nonfailing Heart --;11 The Effect of Disease on Cardiac Glycoside Pharmacokinetics --;12 Clinical Indications and Choice of Cardiac Glycosides, Clinical Conditions Influencing Glycoside Effects --;13 Side Effects and Intoxication of Cardiac Glycosides: Manifestations and Treatment --;14 Interactions Between Cardiac Glycosides and Other Substances in the Body --;Author Index.
(1970) determined an elimination half-life of 14 h in normals as com- pared to 60 h in anuric patients. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in- dicate that the elimination half-life of strophanthin is prolonged in renal failure.