Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect
edited by Giampietro Gasparini, Daniel F. Hayes.
Totowa, NJ
Humana Press Inc
2006
Cancer Drug Discovery and Development
Biomedical and Life Sciences (Springer-11642).
Part I. General Topics Guidelines for the Design of Clinical Studies for the Development and Validation of Therapeutically Relevant Biomarkers and Biomarker-Based Classification Systems Richard M. Simon Analytical Aspects of Biomarker Immunoassays in Cancer Research Fred C. G. J. Sweep, Chris M. G. Thomas, and Manfred Schmitt Tissue Microarrays: State of the Art, Pitfalls, and Promises Chungyeul Kim and Soonmyung Paik Part II. Assays for Gene Expression and Post-Translational Protein Abnormalities Gene Expression Profiling with DNA Microarrays: Revolutionary Tools to Help Diagnosis, Prognosis, Treatment Guidance, and Drug Discovery Michele De Bortoli and Nicoletta Biglia Part III. Assays for DNA Abnormalities Assays for Gene Amplification: State of the Art, Pitfalls, and Promises Chungyeul Kim, Yongkuk Song, and Soonmyung Paik Part IV. Tissue Predictive Biomarkers Cell Kinetics Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori Urokinase-Type Plasminogen Activator and PAI-1: Validated Prognostic Factors for Breast Cancer Michael J. Duffy Predictive Value of c-erb-B2 for Endocrine Therapy and Chemotherapy in Breast Cancer Vered Stearns erb-B2 as a Therapeutic Target Robert Mass The Epidermal Growth Factor Receptor Pathway as a Selective Molecular-Targeted Treatment in Human Breast Cancer Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora p53 as a Prognostic and Predictive Indicator Daniela Kandioler and Raimund Jakesz Part V. Predictive Biomarkers in Body Fluids Occult Metastatic Cells in Breast Cancer Patients: State of the Art, Pitfalls, and Promises Stephan Braun, Julia Seeber, and Christian Marth Circulating HER2/neu: Clinical Utility Allan Lipton, Laurence Demers, Kim Leitzel, Suhail M. Ali, Rainer Neumann, Christopher P. Price, and Walter P. Carney Circulating Vascular Endothelial Growth Factor: Methods, Prognostic Significance, and Potential Application for Antiangiogenic Therapy Roberta Sarmiento, Roberta Franceschini, Sabrina Meo, Massimo Gion, Raffele Longo, and Giampietro Gasparini Detection of Early Tumor Dissemination in Patients with Breast Cancer Debra Hawes and Richard J. Cote Part VI. Future Directions New Technologies/New Markers/New Challenges Daniel F. Hayes and Giampietro Gasparini Index