عنوان

Purine and Pyrimidine Metabolism in Man VII :

1489926380

1489926402

9781489926388

9781489926401

b537474

Purine and Pyrimidine Metabolism in Man VII :

[Book]

Part A: Chemotherapy, ATP Depletion, and Gout

edited by R. Angus Harkness, Gertrude B. Elion, Nepomuk Zöllner.

Boston, MA

Springer US : Imprint : Springer

1991

Advances in experimental medicine and biology, 309A.

Uricase Gene and Evidence that Lysine 164 Is Involved in the Substrates-Binding Site of the Enyzme --;Study of DNA Repair in Peripheral Blood Lymphocytes of Patients with Rheumatic Diseases Undergoing Treatment --;Nucleoside Transport in Lymphocytes from Alcoholics and Non-Alcoholics --;Initial Rate Measurements of Cellular Nucleoside Transport: Time Course, Initial Curvature of Time Curves and Metabolism --;Relationships between Metabolic Enzymes and the Nucleoside Transport --;Active Transport of Adenosine into Primary Cultures of Brain Cells and its Methodological Consequences --;Intestinal Transport and Metabolism of Purine and Pyrimidine Nucleosides --;Guanine Uptake by Human Erythrocytes --;Radioligand Binding Studies on the Nucleoside Transport Protein --;Nucleoside Transport in Guinea-Pig Myocardium --;Comparison of the Existing Nucleoside Transport Inhibitors: in Vitro and in Vivo --;Effect of Membrane Lipid Composition on the Functional Activity of a Reconstituted Nucleoside Transporter Derived from Ehrlich Ascites Cells --;Antibodies and Proteases as Probes of the Structures of Mammalian Nucleoside Transporters --;Expression of Sodium Dependent-Nucleoside Transporters in Xenopus Oocytes --;Control of Nucleoside Transport in Neural Cells. Effect of Protein Kinase C Activation --;Isolation of Nucleoside Permeases from Escherichia coli --;Murine Erythroleukemia Cells and Resistant to Periodate-Oxidised Adenosine have Lowered Levels of Nucleoside Transporter --;Effect of Ischemia on Cardiac Adenosine Binding Sites --;A Ferritin-Cyclohexyladenosine Probe for Electron Microscopical Localization of A1 Adenosine Receptor --;Effect of Adenosine on the Membrane Potential Changes of Human Neutrophils Triggered by the Tripeptide F-Met-Leu-Phe --;A2 Adenosine Receptors in Neutrophils from Healthy Volunteers and Patients with Rheumatic Disease.

Biochemical Approach to New Medications --;Antimetabolites in Cancer Chemotherapy --;2-Chlorodeoxyadenosine Chemotherapy Triggers Programmed Cell Death in Normal and Malignant Lymphocytes --;ICI D1694, an Inhibitor of Thymidylate Synthase for Clinical Study --;Action and Sequence Dependent Interaction of Acivicin and 6-Thioguanine in the Human Derived Maligant T-ALL and CALLA+ Cell Lines --;Conversion of Acyclic Nucleoside Phosphonates to their Diphosphate Derivatives by 5-Phosphoribosyl-1-Pyrophosphate (PRPP) Synthetase --;Derivation of New Drugs for Therapy of AIDS --;Biochemical and Pharmacological Properties of C1-972, a Novel 9-Deazaguanine Analog Purine Nucleoside Phosphorylase (PNP) Inhibitor --;Pyrrolo[3,2-D]pyrimidines, a New Class of Purine Nucleoside Phosphyorylase (PNP) Inhibitors as Potential T-cell Selective Immunosuppressive Agents --;Modulation of Metabolism and Anti-HIV-1 Activity of Purine 2?,3?-Dideoxynucleosides by IMP Dehydrogenase Inhibitors --;Acadesine (AICA Riboside) Inhibits Platelet Aggregation in Human Whole Blood --;Concentration and Time Dependent Growth Inhibition and Metabolism in Vitro by 2?, 2?-Difluoro-deoyxcytidine (Gemcitabine) --;Thiopurine Methyltransferase Activity and Efficacy of Azathioprine Immunosuppresion in Transplant Recipients --;Increase in 2?,5?-Oligoadenylate Synthetase Caused by Deoxycoformycin in Hairy Cell Leukaemia --;A Dual Anti-Tumour Effect of a Combination of Interferon-? and 5-Fluorouracil or 2-Chlorodeoxyadenosine on Natural Killer (NK) Cell Mediated Cytotoxicity --;The Effect of Methotrexate on the Folate Coenzyme Pools in Human Hepatoma Cells in Culture --;Purine Nucleotide Biosynthesis in Leukemic Promyelocytes Treated with Retinoids --;6-Mercaptopurine Metabolism in Two Leukemic Cell Lines --;Synergistic Interaction of Methotrexate and 6-Mercaptopurine in Human Derived Malignant T-and CALLA+ Cell Lines --;6-Thioguanine Metabolism in Human Erythrocytes --;The Impact of Selected Nucleosides on the Cytotoxicity of ARA-C in HL60 Cells --;Effect of Chloroadenosine on the Phosphoinosotide Turnover in Human T Lymphoblasts Activated through the T-cell Receptor/CD3 Complex --;Isolated Liver Perfusion versus Hepatic Artery Infusion with 5-Fluorouracil in a Rat Model; Effects on Thymidylate Synthase --;Changes of Purine Nucleotide Metabolism of Ehrlich Ascites Cells during the Transition of Tumour Growth --;Purine Nucleotides, Nucleosides and Nucleobases of Liver, Skeletal Muscle, Blood and Tumour Cells during the Growth of Ehrlich Ascites Tumour in Mice --;Uridine Fluxes in Healthy Proliferating T-Lymphocytes, MOLT-3 T-ALL Cell-Line Cells and Differentiated MOLT-3 Cells --;Some Aspects of Purine Nucleotide Metabolism in Human Lymphocytes: Nucleotide Content in Human Lymphoblastoid Lines, Transfected with HIV --;Metabolism and Action of 2?, 2?-Difluoro-deoxycytidine: Self Potentiation of Cytotoxicity --;Effect of Leucovorin on 5-Fluorouracil Induced Inhibition of Thymidylate Synthase in Patients with Colon Cancer --;A Novel Xanthine Dehydrogenase Inhibitor (BOF-4272) --;Changes Caused by Ethanol Intake on Metabolism of Hypouricemic Agents (Combination of Allopurinol and Benzobromarone) --;Allopurinol in Breast Milk --;Pharmacokinetics of Benzbromarone: Evidence for a Biliary-Intestinal Biliary-Recirculation --;Analysis of Uric Acid Transport in Renal Tubules Using Benzbromarone and Pyrazinamide --;Deficient Benzbromarone Elimination from Plasma: Evidence for a New Genetically Determined Polymorphism with an Autosomal Inheritance --;Nucleotide Status in Erythrocytes of Rats Infected with Plasmodium berghei --;Hypoxanthine Depletion Induced by Xanthine Oxidase Inhibits Malaria Parasite Growth in Vitro --;New Nucleoside Transport Pathways Induced in the Host Erythrocyte Membrane of Malaria and Babesia Infected Cells --;Effect of Polyethylene Glycol-Modfied Adenosine Deaminase (PEG-ADA) Therapy in Two ADA-Deficient Children: Measurement of Erythrocyte Deoxyadenosine Triphosphate as a Useful Tool --;Urate Transport in the Proximal Tubule of Human Kidney --;The Genetics of Renal Excretion of Urate in Man --;What is the Pathogenesis of Familial Juvenile Gouty Nephropathy? --;Renal Urate Hypoexcretion Preceding Renal Disease in a New Kindred with Familial Gouty Nephropathy (FJGN) --;Familial Nephropathy and Gout: Which Comes First? --;Does Allopurinol Affect the Progression in Familial Juvenile Gouty Nephropathy? --;Congenital Chloride Losing Enteropathy Associated with Tophaceous Gouty Arthritis --;The Role of Lead in Gout Nephropathy Reviewed: Pathogpenic or Associated Factor? --;Myogenic Hyperuricemia in Hypoparathyroidism --;Lipoprotein Metabolism in Primary Gout Influence of Alcohol Intake and Body Weight --;Serum Urate and Uric Acid Excretion --;Gout and Main Rheumatic Diseases in Man --;Importance of Confounding Factors Age and Sex in the Correlation of Serum Uric Acid, Cholesterol and Triglyceride Levels --;Changes in Urate Metabolism after Castration of Patients Suffering from Carcinoma of the Prostate --;Renal Hypouricemia Associated with Hyperoxypurinemia due to Decreased Renal Excretion of Oxypurines: A New Defect in Renal Purine Transport --;Significance of Hypouricemia --;Organic Distribution and Interrelationships of Lesions Occuring in Laying Hens Suffering from Gout and Urolithiasis --;Biochemical Investigations on Chicken Gout Observed in the Marmara Region in Turkey --;Production of Uric Acid and Allantoin in Perfused Rat Liver --;Dynamics in the Purine Nucleotides of Liver during Various Periods of Hypoxia/Ischaemia and Reoxygenation --;Adenosine Origin and Clinical Roles --;Oxypurines in Extracellular Fluids from Piglets during Hypoxemia and Reoxygenation --;Regulation of Adenosine Concentrations by Acadesine (AICA-Riboside) in Human B-Lymphoblasts --;Preservation of Adenine Nucleotides following Ischemia and Reperfusion: Correlation with Functional Recovery --;An Alternative Pathway of Adenylate and ATP Synthesis --;Preservation of Nucleotide Pool during Heart Transplantation and Evaluation of Adenylate Catabolic Pathways in the Human Heart --;The Influence of Acetate on Adenine Nucleotides in Rat Liver --;Purine Nucleotide Catabolism in Rat Liver after Castration --;Adenine Nucleotide Metabolism in Liver Ischemia: Effect of Allopurinol --;Effect of Pulsed Electromagnetic Fields on the Adenine Nucleotide Pool and Energy Charge in Cells in Culture --;Mechanism Accounting for Changes of Adenine Nucleotide Content in Mitochondria at Ischemia --;New Aspects of Purine Nucleotide Metabolism: Formation of ADP from Inorganic Phosphate during Degradation of AMP --;Phosphorylation of Adenosine by an Exchange Reaction between AMP and Adenosine in Anoxic Hepatocytes --;Hypoxanthine and Inosine Metabolism in Cultured Rat Cardicmyocytes --;The Mechanism of Conversion of Xanthine Dehydrogenase to Oxidase and the Role of the Enzyme in Reperfusion Injury --;Purification of Xanthine Oxidase from Human Milk --;Mechanisms of Protection of Hepatocytes at Anoxia and Rejoxygenation by the Xanthine Oxidase Inhibitor Oxypurinol --;Oxypurinol Reduced Ischaemic Brain Injury in the Gerbil and Rat --;Acadesine (AICA Riboside) Attenuates Reperfusion Injury and Oxidant-Induced Damage of the Heart --;Effects of H2O2 and CHPO on ATP, CP Content and 14 C-HX Uptake by HUVECS --;Absence of Xanthine Oxidoreductase Activity in Human Myocardium --;Lower Xanthine Oxidoreducatase Activity in Isolated Perfused Hearts if Xanthine Replaces Hypoxanthine as Substrate --;Evidence from in Vitro Studies that Dihydroorotate Dehydrogenase May Be a Source of Toxic Oxygen Species --;Influence of Oxipurinol on Colitis Induced in Rat Colon by Trinitrobenzensulfonic Acid Treatment --;A Xanthinuric Family --;the Proposita having Immunologically Reactive Xanthine Oxidase but no Xanthine Oxidase Activity --;Human Hepatic Peroxisomes with Crystalloid Cores Associated with Urate Oxidase Activity --;Structural Analysis of the Rat

Proceedings of the Seventh International/Third Joint Symposium held in Bournemouth, UK, June 30-July 5, 1991

Proceedings of the Seventh International/Third Joint Symposium held in Bournemouth, UK, June 30-July 5, 1991

Biochemistry.

Life sciences.

edited by R. Angus Harkness, Gertrude B. Elion, Nepomuk Zöllner.

Gertrude B Elion

Nepomuk Zöllner

R Angus Harkness

[Book]

Y