عنوان

Antiangiogenic agents in cancer therapy /

1588298701

1597451843

9781588298706

9781597451840

dltt

Antiangiogenic agents in cancer therapy /

[Book]

edited by Beverly A. Teicher, Lee M. Ellis

2nd ed

1 online resource (xviii, 559 pages, 26 unnumbered pages of plates) :

illustrations (some color)

Cancer drug discovery and development

Includes bibliographical references and index

Basic biology of angiogenesis -- Vascular endothelial growth factor family and its receptors -- Cycle between angiogenesis, perfusion, and hypoxia in tumors -- Role of integrins in tumor angiogenesis -- Tumor endothelial cell abnormalities -- Extracellular matrix and VEGF processing -- Endothelial precursor cells -- Role of pericytes in angiogenesis -- Newer vascular targets -- Chemokines in angiogenesis -- Angiopoietin/Tie2 signaling regulates tumor angiogenesis -- Imaging angiogenesis -- Tumor blood vessels: structure, function, and classification -- Lymphatic system in the pathology of cancer -- Translational research in tumor angiogenesis -- VEGF in the adult: implications for anti-VEGF therapies -- Normalization of tumor vasculature and microenvironment: a potential mechanism of action of antiangiogenic therapies -- Metronomic low-dose antiangiogenic chemotherapy in mice and man -- Small-molecule vascular disrupting agents in cancer therapy -- Normalization of tumor vasculature and improvement of radiation response by antiangiogenic agents -- Challenges in translating antiangiogenic therapy from the bench to bedside -- Regulation of angiogenesis in cancer and its therapeutic implications -- Antiangiogenic therapy in the clinical trial results and future directions -- Angiogenesis and angiogenesis inhibition in sarcomas -- Antiangiogenesis agents in colorectal cancer -- Antiangiogenic therapy for primary CNS tumors -- Angiogenesis inhibitors for the treatment of lung cancer -- Antiangiogenic therapy of renal cell carcinoma -- Antiangiogenesis therapies in gynecologic malignancies -- Antiangiogenic agents in myeloid malignancies -- Angiogenesis in malignant and non-malignant pediatric tumors -- Prognostic and predictive significance of surrogate biomarkers of angiogenesis -- Endpoints for the determination of efficacy of antiangiogenic agents in clinical trials -- Role of imaging in the clinical development of antiangiogenic agents

0

Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of

Springer

978-1-58829-870-6

Antiangiogenic agents in cancer therapy.

1588298701

Neovascularization inhibitors.

HEA-- 039030

MED-- 062000

Ellis, Lee M.

Teicher, Beverly A.,1952-

Ohio Library and Information Network

20180802031213.0

pn

[Book]

Y