Overview: the pathobiology of head and neck cancer -- Molecular features and treatment modalities of classic versus human papilloma virus-associated head and neck cancer -- Epidemiology of HPV in head and neck cancer: variant strains, discrete protein function -- EGFR inhibitors as therapeutic agents in head and neck cancer -- The role of HCF/c-MET in head and neck squamous cell carcinoma -- Insulin-like growth factor-1 receptors in head and neck cancer -- The P13K signaling pathway in head and neck squamous cell carcinoma -- Jak/STAT signaling in HNC -- TGF[beta] regulates EMT in head and neck cancer -- The Wnt/[beta]-catenin signaling circuitry in head and neck cancer -- Human papillomaviruses (HPV)-positive head and neck cancer and the Wnt signaling pathway -- p53 in head and neck cancer -- DNA damage proteins and response to therapy in head and neck cancer -- Hypoxia and radioresistance in head and neck cancer -- Sequencing HNC: emergence of notch sequencing -- Gene expression in HNC -- Projections: novel therapies for HPV-negative cancers of the head and neck