Epidemiology and risk factors. Incidence and outcome of schizophrenia across the globe / Paulo R. Menezes -- Gene-environment interactions for searchers: collaboration between epidemiology and molecular genetics / Jim van Os, Bart P.F. Rutten, and Richie Poulton -- The natural history of the course and outcome of schizophrenia / Judith Allardyce and Jim van Os -- Impact of contextual environmental mechanisms on the incidence of schizophrenia and other psychoses / James B. Kirkbride -- Pathophysiology. Disinhibition of prefrontal cortex neurons in schizophrenia / B. Moghaddam and A.L. Pehrson -- Brain anatomical abnormalities in schizophrenia: neurodevelopmental origins and patterns of progression over time / Geraldo F. Busatto, Marcus V. Zanetti, Maristela S. Schaufelberger, and José A.S. Crippa -- The neuropathology of schizophrenia: central role for the hippocampus? / Peter Falkai, Eleni Parlapani, Oliver Gruber, and Andrea Schmitt -- Molecular neuroimaging, pathophysiological mechanisms, and drug discovery / Philip McGuire -- Genetics. Animal models of schizophrenia: focus on hippocampal disruption of dopamine system regulation / Anthony A. Grace -- Genetic and proteomic studies in schizophrenia / Emmanuel Dias-Neto, Daniel Martins-de-Souza, Elida P.B. Ojopi, and Wagner F. Gattaz -- Neurogenetic risk mechanisms of schizophrenia: an imaging genetics approach / Andreas Meyer-Lindenberg -- Progress in genetic studies of schizophrenia / Renan P. Souza, Marco A. Romano Silva, and James L. Kennedy -- Psychopathology, cognition, outcome. Prediction of psychosis through the prodromal syndrome / Tyrone D. Cannon -- Schizophrenia as a cognitive disorder: recent approaches to identifying its core cognitive components to aid treatment development / Keith H. Nuechterlein, Michael F. Green, and Robert S. Kern -- Cognitive and social processes in psychosis: recent developments / Daniel Freeman -- The impact of early intervention in schizophrenia / Alison R. Yung, Eoin J. Killackey, Barnaby Nelson, and Patrick D. McGorry -- The cross-sectional and longitudinal architecture of schizophrenia: significance for diagnosis and intervention? / Wolfgang Gaebel, Wolfgang Wölwer, Mathias Riesbeck, and Jürgen Zielasek -- Schizophrenia and other psychotic disorders: boundaries and similarities. Continua or classes? Vexed questions on the latent structure of schizophrenia / Richard J. Linscott, Mark F. Lenzenweger, and Jim van Os -- Integrating the epidemiology and pathogenesis of schizophrenia from the street to the striatum: integrating the epidemiology and pathogenesis of schizophrenia / Robin M. Murray, Marta Di Forti, and Oliver Howes -- Cannabis: a clue or a distraction in the search for 'causes' of psychosis? / John McGrath and Louisa Degenhardt -- The 'totality' of psychosis: epidemiology and developmental pathobiology / Olabisi Owoeye, Tara Kingston, Robin J. Hennessy, Patrizia A. Baldwin, David Browne, Paul J. Scully, Anthony Kinsella, Vincent Russell, Eadbhard O'Callaghan, and John L. Waddington -- Treatment. Comparative efficacy and safety of first- and second-generation antipsychotics in the treatment of schizophrenia: facts and fiction / Rajiv Tandon, and Babu Rankapalli -- Long-acting antipsychotic medication and the outcome of schizophrenia / Anthony S. David, Ayana Gibbs, and Maxine X. Patel -- Modern community care strategies for schizophrenia care:impacts on outcome / Tom Burns -- Does stigma impair treatment response and rehabilitation in schizophrenia? The "contribution" of mental health professionals / Wulf Rössler -- Treatment of schizophrenia: discussion / Shôn Lewis