Pulp and periradicular pathways, pathosis, and closure / Mahmoud Torabinejad -- Chemical properties of mineral trioxide aggregate / David W. Berzins -- Physical properties of mineral trioxide aggregate / Lawrence Gettleman and Ricardo Caicedo -- Use of MTA in vital pulp therapy / Till Dammaschke, Joe Camp, and George Bogen -- Use of MTA in teeth with necrotic pulps and open apices / Shahrokh Shabahang and David Witherspoon -- Use of MTA in regenerative endodontics / Mahmoud Torabinejad, Robert P. Corr, and George T.J. Huang -- Use of MTA as root perforation repair / Mahmoud Torabinejad and Ron Lemon -- Root canal obturation with MTA / George Bogen, Ingrid Lawaty, and Nicholas Chandler -- Use of MTA as root end filling / Seung-Ho Baek and Su-Jong Shin -- Calcium silicate-based cements / Masoud Parirokh and Mahmoud Torabinejad