Basic considerations -- Epidemiology of osteoarthritis -- Etiopathogenesis of osteoarthritis -- Pathology of osteoarthritis -- Cell biology, biochemistry, and molecular biology of articular cartilage in osteoarthritis -- Experimental models of osteoarthritis -- Molecular genetics of osteoarthritis -- General aspects of diagnosis -- Osteoarthritis: clinical presentations -- Radiologic diagnosis -- Magnetic resonance imaging -- Ultrasound and alternative imaging outcomes -- Laboratory findings in osteoarthritis -- Noninvasive biochemical markers in osteoarthritis -- Secondary osteoarthritis -- General aspects of management -- Baseline program -- Pharmacologic treatment of osteoarthritis -- Intra-articular therapy -- Complementary and alternative medicine -- Study design and outcome measures in osteoarthritis clinical trials -- Surgical considerations in osteoarthritis -- General considerations, indications, and outcomes -- Upper extremity considerations: osteoarthritis of the shoulder -- Upper extremity considerations: hand, wrist, and elbow -- Lower extremity considerations: hip -- Lower extremity considerations: knee -- Lower extremity considerations: foot and ankle -- Osteoarthritis of the spine -- New frontiers in surgery of osteoarthritis