Modern tools for the synthesis of complex bioactive molecules /
[Book]
edited by Janine Cossy, Stellios Arseniyadis
xiii, 581 pages :
illustrations (some color) ;
24 cm
Includes bibliographical references and index
C-H functionalization: a new strategy for the synthesis of biologically active natural products / Sophie Rousseaux, Benoît Liégault, and Keith Fagnou -- The Negishi cross-coupling in the synthesis of natural products and bioactive molecules / Evelina Colacino, Jean Martinez, and Frédéric Lamaty -- Metal-catalyzed C-heteroatom cross-coupling reactions / Renata Marcia de Figueiredo, Jean Marc Campagne, and Damien Prim -- Golden opportunities in the synthesis of natural products and biologically active compounds / Fabien Gagosz -- Metathesis-based synthesis of complex bioactives / Jean-Alexandre Richard, Sin Yee Ng, and David Y.-K. Chen -- Enantioselective organocatalysis: a powerful tool for the synthesis of bioactive molecules / Mitsuru Shoji and Yujiro Hayashi -- Asymmetric phase-transfer catalysis / Seiji Shirakawa, Shin A. Moteki, and Keiji Maruoka -- Rearrangements in natural product synthesis / José Marco-Contelles and Elena Soriano -- Domino reactions in the enantioselective synthesis of bioactive natural products / Lutz F. Tietze, Scott G. Stewart, and Alexander Düfert -- Fluorous linker-facilitated synthesis of biologically interesting molecules / Wei Zhang -- The evolution of immobilized reagents and their application in flow chemistry for the synthesis of natural products and pharmaceutical compounds / Rebecca M. Myers ... [et al.] -- Synthetic approaches to bioactive carbohydrates / Xavier Guinchard, Sébastien Picard, and David Crich -- Ammonium ylides as building blocks for alkaloid synthesis / Scott Bur and Albert Padwa -- Precursor-directed biosynthesis of polyketide and nonribosomal peptide natural products / Colin J. B. Harvey and Chaitan Khosla -- Target-oriented and diversity-oriented organic synthesis / Raphaël Rodriguez -- DNA as a tool for molecular discovery / Michael Smietana ... [et al.]
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"An overview of the new technologies that have revolutionized organic chemistry and allowed easy access to complex bioactives, this book brings modern synthetic techniques and bioactives together. The synthesis of structurally complex molecules has become a real challenge for the synthetic community. The development of innovative methodologies enabling control of the exact connectivity of the atoms within a molecule and setting correct three-dimensional arrangements, have gained a great interest. Combining representative experimental procedures for particular methods, the book is suited for advanced students, researchers, and pharmaceutical employees"--
"This book provides an overview of the new technologies that have revolutionized organic chemistry and allowed an easy access to very important complex bioactives. It is the only book of its kind assocating modern synthetic techniques and structurally complex bioactives, and includes some representative experimental procedures for particular methods. The synthesis of structurally complex molecules has become a real challenge among the synthetic community"--