عنوان

Heart failure :

0470015977

9780470015971

dltt

Heart failure :

[Book]

molecules, mechanisms and therapeutic targets /

[Novartis Foundation].

Chichester, UK :

John Wiley,

2006.

x, 291 pages :

illustrations.

Novartis Foundation symposium ;

274

"Symposium on heart failure: molecules, mechanisms and therapeutic targets, held at the Novartis Foundation, 26-28 April 2005"--Page v.

Includes bibliographical references and indexes.

Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation / E.N. Olson [and others] -- A novel mechanism of mechanical stress-induced hypertrophy / H. Akazawa [and others] -- Controlling cardiomyocyte survival / N. de Jonge [and others] -- Mechanisms of angiotensin II-dependent progression to heart failure / M. Nemer [and others] -- Alterations in myocardial gene expression as a basis for cardiomyopathies and heart failure / M.R. Taylor and M.R. Bristow -- Role of the insulin-like growth factor 1 (IGF1)/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy / J.R. McMullen and S. Izumo -- Role of Akt in cardiac growth and metabolism / A.J. Muslin and B. DeBosch -- Novel therapy for heart failure and exercise-induced ventricular tachycardia based on 'fixing' the leak in ryanodine receptors / A.R. Marks -- Phospholamban as a therapeutic modality in heart failure / G. Chu and E.G. Kranias -- Sarcomere protein gene mutations and inherited heart disease: A [beta]-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure / M. Kamisago [and others] -- The cardiomyocyte cell cycle / P.J. Lafontant and L.J. Field -- Restoration of cardiac function with progenitor cells / C. Urbich [and others] -- Signalling pathways in cardiac regeneration / M.P. Santini [and others] -- Beyond small molecule drugs for heart failure: Prospects for gene therapy / K.R. Chien -- Dual roles of telomerase in cardiac protection and repair / M.D. Schneider.

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Describes the work of leading investigators studying the basic mechanisms of cardiac growth, function and dysfunction. There are also contributions from researchers developing novel therapeutic strategies for cardiac disease. The unique feature is the discussions amongst the contributors, which always return to the same basic problem: how can new data from biological studies be used to design novel therapies for the treatment of cardiac dysfunction following myocardial infarction, hypertension and other disorders?

Heart-- Adaptation.

Heart failure-- Treatment-- Pathophysiology.

Heart failure.

Heart Failure-- etiology.

Heart Failure-- therapy.

Novartis Foundation.

Symposium on Heart Failure: Molecules, Mechanisms and Therapeutic Targets(2005 :, Novartis Foundation)

20171021021827.0

[Book]

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